Chevy Equinox 2LT
The Chevy Equinox 2LT is great for large people because it has a lot of adjustability. There is a lot of footroom, legroom, headroom, etc.. In addition the Equinox comes with a lot of cool features like a rear view backup camera which makes everything so much easier.
The Kia Optima is great because it has a lot of headroom and legroom and even with the front seat pushed back there is still plenty of room for the rear passengers. The only drawback possibly is the short seats which do not have very much thigh support but if you can overlook that check it out.
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The Honda Odyssey is just great for large people and it will seat many more people than a sedan. It has great legroom and headroom and is easy to get in and out of. Also if you ever need to haul a large amount of groceries or anything else of medium size the back of the Odyssey is spacious and roomy.
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The Hyundai Azera is a good choice of a sedan especially in terms of leg and headroom and because it's a Hyundai it wont set you back too much. see more on Hyundai Grandeur
If you are in the market for a sports car a Nissan 300ZX is a great choice for big and tall people. They don't make them anymore but you can pick up a used one quite easily for a good price. see more on The Third Generation (Z31): 300ZX
The Ford Focus is another compact that's good for large people. It's not the biggest or the roomiest but it's got great value for the price so try it out and see if you like it.
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The Golf is another compact that is easy on the wallet but still has a lot of room. You can't fault the german engineering and if you want to look good this is the car to get.
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The Sebring screams comfort for large people with its roomy interior. It may be a little hard to get in and out of but it's another great choice for those that are big. see more on Chrysler Sebring