The greatest sarcastic TV doctor of all time, House M.D., had plenty of famous people throughout his eight-season, 177-episode-long run. These actors typically had episode-long guest appearances on House, as opposed to brief cameos, and many times these guest stars were so impressive that their performances stole the show.
Episode: Love Is Blind
Role: Will Westwood
In this season eight episode, Jordan plays a blind man who is dealing with a mysterious illness at a terrible time, shortly before he’s going to propose to his girlfriend. His condition worsens and the team initially saves him, but he feels his side effects are worse than dying would’ve been.
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Seyfried appeared in the first season of the show, playing Pam, the girlfriend of Keith Foster. Her boyfriend is the patient focused on this episode, who coughed up blood while driving, resulting in a car accident. This was shortly after her role as Karen in Mean Girls, so definitely a change of style, but she also appeared on CSI and Law & Order: SVU.
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Role: Jimmy Quidd
Before Renner was staring in Avengers movies, he appeared n the fourth season of House as a punk rock musician who falls ill, collapsing right before going on stage. In addition, he’s coughing up blood and dealing with a fever, and discovering his diagnosis becomes House and company’s top priority in this episode.
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Episode: Open And Shut
More commonly known as Lori from The Walking Dead, Sarah Wayne Callies starred in this season six episode of House back in 2010. Her character Julia is in an open marriage, which is evident from the opening scene when she’s about to hook up with someone, but her husband unexpectedly drops in to pick up something. Instead of getting angry, he apologizes for interrupting and leaves to let her do her thing, but she begins having intense abdominal pain and winds up in the hospital, being treated by Thirteen, Chase, Forman, and Taub, who is intrigued by her open relationship. see more on Sarah Wayne Callies
Episode: Locked In
Mos Def isn’t just a rapper, he’s also a heck of an actor, who shows off his talent in this episode, playing Lee, who is suffering from locked-in syndrome. We see things from Lee’s perspective, as House realizes that he’s not brain dead like another physician said he was after his bicycle accident. He communicates with House and eventually, regains voluntary movement and speaks.
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Episode: The Tyrant
Role: President Dibala
Earl Jones’s character in this season four episode is a cutthroat dictator in Africa who finds himself a patient in the hospital, assigned to Dr. Foreman. When Foreman asks for Chase’s help treating this horrible man, Chase hides what Dibala’s actual illness is, leading to Foreman giving him incorrect treatment that kills him.
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On the season two premiere episode, LL plays a death row prison inmate who committed four murders – his girlfriend, a prison guard, and two inmates. While exercising, he begins hallucinating about the people he’s killed, screaming before collapsing. He finds himself in the hospital, assigned to a cardiologist until Dr. House asks to take the case because he’s so intrigued.
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Episode: The Mistake
Role: Sam McGinley
On this season two episode, we see the fallout of Chase making a mistake that resulted in a patient’s death. The patient was Kayla McGinley, and Hurst plays her brother Sam, who is unhappy with how long his sister had to wait to be treated. He sues the hospital and winds up settling with Cuddy, leading to Chase and House facing discipline. see more on Ryan Hurst