Top 15 Times Oprah Has Lost It

This clip kicks off with a bang as John Travolta and best friend Gayle King introduce her next surprise for her 50th birthday bash having come all the way from Switzerland to tell Oprah she is "Simply the Best."

Oprah screams and jumps up as Tina Turner bursts through a door atop a staircase and starts singing.

Oprah lets loose her inner jitter bug and even sings along aside Stedman and Gayle as Tina serenades her. We meet Oprah's awestruck O face again and again in this video, the most notable appearance happening about 1:14 into the clip, and lasting long enough to suspect Stedman had to be jealous.

Jay-Z stopped by the show to plug his new album, The Blueprint, in 2008.

He starts to freestyle and encourages Oprah to join in. Obviously, this is a new venture for her as she asks "you're just making it up, right now?"

Jay-Z picks back up, spitting rhymes and she truly looks bewildered for a very rare moment as she bobs around and attempts to hang with her Brooklyn homie.

Jay-Z stops and gives her some direction as the audience is cracking up. The two come up with a rhyme and she tries to follow along and throw in a word here and there. Her little girl face as she looks at Jay-Z for approval at 1:44 is priceless.

Eventually they get through the few stanzas and Oprah goes back to what she knows best as she sends the show into a commercial break.

Oprah gets into a heated discussion with members of her audience regarding the 'one way' street to God via Jesus.

This is a clip that ends up getting her in trouble with more than one religious advocate because she suggests that there are other ways to find enlightenment in God than simply through Jesus.

At 1:24 Oprah says "there couldn't possibly be just one way" to God as more than one audience member vehemently disagrees, several members of the audience rebuke her and argue with her, suggesting she is "buying into the lie."

Oprah offers a hypothetical example of a person who lives in a remote part of the world and had never heard of the Son of God but lives his life in a godly manner. She says "does God care about your heart or does God care if you call His Son Jesus?" The argument continues briefly until Oprah throws in the towel and decides not to argue religion on her show.

There was actually a ton of backlash from these reasonably enlightened comments Oprah made this day, extremists went so far as to label her the Antichrist for publicly denying Jesus,

Oprah introduces Susan Lucci at the Daytime Emmy Awards and Susan turns it around by showing an old clip of Oprah as a guest on her soap opera when she was just starting out.

Oprah acts embarrassed until Susan professes her love for Oprah and the girls go back and forth fawning over each other, inappropriately and effectively wasting that precious 'awards-ceremony-time.'