What Happened in Real Life: Star and sitcom legend John Ritter died in 2003 from an undiagnosed aortic dissection.
What Happened on the Show: After a two-month hiatus, Ritter's character was said to have died following a collapse while shopping for milk at the grocery store. The show only lasted one more season.
Also Rankedsee more on 8 Simple Rules
What Happened in Real Life: In 2008, actor Stanley Kamel died of a heart attack between seasons six and seven.
What Happened on the Show: Kamel's character, Monk's therapist Dr. Charles Kroger, also died of a heart attack in an episode dedicated to Kamel. The show lasted for eight seasons and Dr. Kroger appeared in clips in later episodes.
#21 on The Best Dramedy TV Seriessee more on Monk
What Happened in Real Life: Saturday Night Live alum Phil Hartman was shot to death by his wife while he was sleeping in May 1998. The fourth season of NewsRadio had already wrapped at the time of his death.
What Happened on the Show: Hartman's character was said to have died of a heart attack in the first episode of season five. Due to poor ratings and reviews, the show only lasted one more season.
#71 on The Best TV Shows to Rewatchsee more on NewsRadio
What Happened in Real Life: Actor Will Lee, who played the beloved Mr. Hooper, died of a heart attack in December 1982.
What Happened on the Show: An episode called "Farewell Mr. Hooper" acknowledged that Mr. Hooper had passed away, with the other adults explaining his passing to Big Bird. As of 2016, the show is in its 46th season.
#26 on The Best '70s TV Showssee more on Sesame Street
What Happened in Real Life: Lung cancer and emphysema took the life of actress Nancy Marchand, who played the feisty Livia Soprano.
What Happened on the Show: In a rare move, the producers used CGI and existing footage to give Livia one final scene before the character died in her sleep in the third season. The show went on to win numerous awards and lasted for a total of eight seasons before ending as one of the most-loved shows in HBO history.
Also Rankedsee more on The Sopranos
What Happened in Real Life: David Strickland, who played rock music reporter Todd Stities, committed suicide in March 1999.
What Happened on the Show: The producers of Suddenly Susan decided to deal directly with Strickland's death on the show, but in an ambiguous manner. His character did not show up for work in the third season finale, leading Susan to look into his absence. The episode ends without revealing what happened to the character, but an ominous phone call hints at the truth. The fourth season saw a large chunk of the original writers, producers, and actors leaving the show. Suddenly Susan was canceled after season four.
#47 on The Best 1990s NBC Showssee more on Suddenly Susan
What Happened in Real Life: The West Wing's White House Chief of Staff Leo McGarry was played by actor John Spencer, who died of a heart attack during the show's final season.
What Happened in the Show: The McGarry character also was said to have died of a heart attack on election night in season seven. Actor and West Wing President Martin Sheen read a tribute to John Spencer before one of the show's final episodes.
#29 on The Best Dramedy TV Seriessee more on The West Wing
What Happened in Real Life: Actress and Where in the World is Carmen Sandiego host Lynne Thigpen suffered a cerebral hemorrhage and died during the third season of The District.
What Happened on the Show: Thigpen's character Ella Farmer died suddenly in an episode shot about three weeks after her funeral. The show lasted for one more season.
Also Rankedsee more on The District