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Cyanosis is the appearance of a blue or purple coloration of the skin or mucous membranes due to the tissues near the skin surface having low oxygen saturation. Based on Lundsgaard and Van Slyke's work, the onset of cyanosis is classically described as occurring if 5.0 g/dL of deoxyhemoglobin or greater is present. What is commonly forgotten, however, is that this was based on an "estimate" of capillary saturation based on a mean of arterial versus peripheral venous...

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