Dysfunctional uterine bleeding

Dysfunctional Uterine Bleeding (DUB) is abnormal genital tract bleeding based in the uterus and found in the absence of demonstrable structural or organic pathology. It is usually due to hormonal disturbances: reduced levels of progesterone causes low levels of pgf2 alpha and causes menorrhagia; increased levels of tissue plasminogen activator (TPA) (a fibrinolytic enzyme) leads to more fibrinolysis. Diagnosis must be made by exclusion, since organic pathology must first be ruled out. It can be classified as ovulatory or anovulatory, depending on whether ovulation is occurring or not. Some sources state that the term implies a hormonal mechanism. 10% of cases occur in women who are ovulating, but progesterone secretion is prolonged...