Freckle

Freckles are clusters of concentrated melanin which are most often visible on people with a fair complexion. A freckle is also called an "ephelis." Freckles can be found on anyone no matter the background, however, having freckles is gene and is related to the presence of the dominant melanocortin-1 receptor MC1R gene variant. The formation of freckles is triggered by exposure to sunlight. The exposure to UV-B radiation activates melanocytes to increase the melanin production, which causes freckles to beco