The Jefferson-Chalmers Historic Business District is a historic district located on East Jefferson Avenue between Eastlawn Street and Alter Road in Detroit, Michigan. The district was listed on the National Register of Historic Places in 2004. The Jefferson East neighborhood of Detroit is bounded by Alter Road on the east, St. Jean Street on the west, Charlevoix Street on the north, and the Detroit River on the south. Jefferson Avenue runs approximately through the center of the Jefferson East neighborhood, and is primarily commercial in nature for thirteen blocks from Dickerson Street to Alter Road. This section of Jefferson Avenue is also known as the Jefferson East Business District. Historically significant structures exist along...