Ménétrier's disease

Ménétrier disease (also known as hyperplastic hypersecretory gastropathy, and named after a French physician Pierre Eugène Ménétrier, 1859–1935), a disorder in which the gastric mucosal folds (rugae) are enlarged (and the total weight of the stomach is increased), making the surface of the stomach look a bit like the brain gyri. This leads to protein loss, parietal cell atrophy, and an increase in mucous cells. It results from profound hyperplasia of the surface mucous cells with accompanying glandular atrophy. The altered gastric mucosa secretes massive amounts of mucus, resulting in low plasma protein levels. The tissue may be inflamed and may contain ulcers. The disease also causes glands in the stomach to waste away and causes the...