The Siege of Calais was fought in early 1558 during the Italian War of 1551���1559. The Pale of Calais had been ruled by England since 1347, during the Hundred Years War. By the 1550s, England was ruled by Mary I of England and her husband Philip II of Spain. When the Kingdom of England supported a Spanish invasion of France, Henry II of France sent Francis Duke of Guise against English-held Calais, defended by Lord Thomas Wentworth, Baron Wentworth. Following failure in mid-1557, a renewed attack captured the outlying forts of Nieullay and Rysbank and Calais was besieged. When the city capitulated, England lost its last territory in France.