Being accused of wrongdoing always stings, but it's especially terrible when you're not guilty. Anime characters who were falsely accused might make you feel righteously indignant on their behalf, but they also spark some seriously intriguing storylines.
Perhaps the most well-known example of this trope is Naofumi Iwatani of The Rising of the Shield Hero, who was falsely accused of assaulting Myne, and is given no opportunity to defend himself. As it turns out, this was all part of a plot to get rid of the Shield Hero. There's also Maria Ross of Fullmetal Alchemist: Brotherhood, who was thought to be responsible for Maes Hughes demise and had to leave the country in order to escape execution. On the lighter side, there's Sorata Kanda, who represents all the male harem protagonists who are constantly being yelled at for getting closer to girls than he actually is.
Which of these cases are the most unfair? That's up to you vote up all the false accusations that made you mad.