Though many anime derive from manga, not every one of those anime follows its source manga closely. When it comes to anime that are different from the manga, plenty of examples come up. Differences between manga and anime versions can arise for all sorts of reasons: an anime geared towards kids may omit the violence seen in the manga or a studio may need to create filler episodes while awaiting the next manga chapter. You may not realize it, but Pokémon's anime and manga versions differ wildly.
Fans often bristle when their favorite manga aren't replicated faithfully. Imagine waiting for your favorite scene from the manga only to find it's substantially changed or entirely cut from the anime version. On the other hand, such differences mean each version can tell a vastly different story. Just look at the details left out of Akira from manga to anime. Occasionally, the original manga falls short of the anime, which can shift up the plot with exciting and unique filler sagas.
When the first Hellsing manga was coming out, there wasn't a lot of manga material with which to work. This meant that the producers needed to come up with their own villain, a particularly powerful vampire named Incognito. Though the war-hungry Nazis of the manga briefly appear, they take a backseat to Incognito's attacks on the Hellsing organization. Hellsing Ultimate, a set of OVAs which began airing five years after the initial series' 2001 release date, followed the then-completed manga more exactingly.
The 2003 version of Fullmetal Alchemist quickly goes off in a different direction from the source manga, a shift that led to the 2009 reboot Fullmetal Alchemist: Brotherhood. While the 2003 version retains many of the main characters from the manga, Fullmetal Alchemist features a new antagonist named Dante, a different method for creating Homunculi, and an ending that drops the protagonist into the middle of World War I. Though a great story, the original Fullmetal anime is not even remotely the same as the manga - if you want to watch that story unfold on-screen, you'll find it in Brotherhood.
The first season of Tokyo Ghoul sticks more or less to the manga, but that changes dramatically during the second season, Tokyo Ghoul √A. In the manga, Ken Kaneki works against Aogiri Tree, an organization attempting to bring liberation to ghouls through violent means, including kidnapping and terrorism. In the anime, Kaneki takes the opposite approach, joining Aogiri Tree instead. On one hand, Tokyo Ghoul √A presents a fresh storyline for Kaneki; on the other, it's frustrating not to see the manga's storyline adapted. In addition to tweaking Kaneki's story, the Tokyo Ghoul anime also removes many of the more violent scenes seen in the manga.
The Fruits Basket manga went on hiatus when artist Natsuki Takaya broke her arm, so the anime ends less than a third of the way through the manga's plotline. Because of this, the Fruits Basket universe differs wildly from anime to manga. The most pronounced differences involve the main villain of the show, Akito Sohma.
In the manga, Akito reveals their identity as a woman, a woman capable of lifting the curse that afflicts the whole family. Yet she remains unwilling to do so because her abusive mom led her to believe that Akito must bind the family to her through the curse, or else face abandonment. In the anime, however, Akito is a man, and is unable to lift the curse - which makes him physically ill - despite a desperate desire to do so. That's just one of many differences between the two versions of Fruits Basket, but few change the tone as dramatically.
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