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The Best 2000s Drama Series 

Ranker TV
Updated November 5, 2019 1.9k votes 312 voters 9.1k views 45 items

List Rules Vote up your favorite dramas that aired on TV in the 2000s

In the mood to catch up some TV you might have missed? This is a good place to start. These are the best 2000s drama series, ranked from best to worst by user votes. From 2000s drama TV series about serial killers, to other good 2000s drama series about mob bosses, a mysterious island, and even vampires!

What shows will you find on this best 2000s drama series list? The Sopranos appears near the top of our list. The 2007 finale of this great 2000s drama show pulled in a whopping 11.9 million viewers who wanted to see how this epic mob story would end. Another good HBO drama from the 2000s was The Wire, starring Dominic West, Idris Alba and Michael K. Williams.

Medical dramas were also quite popular in the 2000s with Grey's Anatomy among the best. Other good shows on this top 2000s drama series list include The Vampire Diaries, Law & Order: Special Victims Unit and Dexter.

Which great 2000s drama should get the top spot on this list? Vote up your favorites!
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1
House is listed (or ranked) 1 on the list The Best 2000s Drama Series
Hugh Laurie, Omar Epps, Robert Sean Leonard

Premiered: 2004

Number of Seasons: 8

Number of Episodes: 177

Network: Fox Broadcasting Company

House (Fox, 2004) is an American television medical drama created by David Shore. The show's main character is Dr. Gregory House, a pain medication-dependent, unconventional, misanthropic ...more

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2
Criminal Minds is listed (or ranked) 2 on the list The Best 2000s Drama Series
Shemar Moore, Matthew Gray Gubler, Thomas Gibson

Premiered: 2005

Number of Seasons: 15

Number of Episodes: 324

Network: A&E, CBS

Criminal Minds (CBS, 2005) is an American police-procedural television program. The series follows a team of profilers from the FBI's Behavioral Analysis Unit based in Quantico, Virginia. The ...more

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3
Castle is listed (or ranked) 3 on the list The Best 2000s Drama Series
Nathan Fillion, Stana Katic, Susan Sullivan

Premiered: 2009

Number of Seasons: 4

Number of Episodes: 105

Network: American Broadcasting Company

Castle (ABC, 2009) is an American crime-comedy-drama television series created by Andrew W. Marlowe. A homicide detective (Stana Katic) reluctantly works with a best-selling mystery novelist ...more

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4
Breaking Bad is listed (or ranked) 4 on the list The Best 2000s Drama Series
Bryan Cranston, Aaron Paul, Anna Gunn

Premiered: 2008

Number of Seasons: 5

Number of Episodes: 54

Network: AMC

Breaking Bad (AMC, 2008) is an American drama television series created and produced by Vince Gilligan. A high school chemistry teacher diagnosed with inoperable lung cancer turns to ...more

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5
Bones is listed (or ranked) 5 on the list The Best 2000s Drama Series
Emily Deschanel, David Boreanaz, Michaela Conlin

Premiered: 2005

Number of Seasons: 9

Number of Episodes: 166

Network: Fox

Bones (Fox, 2005) is an American procedural comedy-drama television series created by Hart Hanson. Forensic anthropologist Dr. Temperance "Bones" Brennan (Emily Deschanel) and cocky ...more

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6
Law & Order: Special... is listed (or ranked) 6 on the list The Best 2000s Drama Series
Mariska Hargitay, Christopher Meloni, Ice-T

Premiered: 1999

Number of Seasons: 21

Number of Episodes: 474

Network: NBC

Law & Order: Special Victims Unit (NBC, 1999) is an American police procedural, legal, crime drama television series set in New York City. In the style of the original Law & Order, ...more

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7
The Sopranos is listed (or ranked) 7 on the list The Best 2000s Drama Series
James Gandolfini, Lorraine Bracco, Edie Falco

Premiered: 1999

Number of Seasons: 6

Number of Episodes: 86

Network: HBO

Watch for Free with Amazon Prime Free Trial The Sopranos (HBO, 1999) is an American crime drama television series created by David Chase. New Jersey mob boss Tony Soprano (James Gandolfini) deals with personal and professional issues in ...more

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8
NCIS is listed (or ranked) 8 on the list The Best 2000s Drama Series
Mark Harmon, Michael Weatherly, Pauley Perrette

Premiered: 2003

Number of Seasons: 17

Number of Episodes: 395

Network: CBS

NCIS is an American police procedural drama television series, revolving around a fictional team of special agents from the Naval Criminal Investigative Service, which conducts investigations ...more

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9
The Vampire Diaries is listed (or ranked) 9 on the list The Best 2000s Drama Series
Nina Dobrev, Paul Wesley, Ian Somerhalder

Premiered: 2009

Number of Seasons: 4

Number of Episodes: 89

Network: The CW

The Vampire Diaries (The CW, 2009) is an American supernatural teen drama television series developed by Kevin Williamson and Julie Plec, based on the book series by L. J. Smith. In the ...more

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10
Law & Order is listed (or ranked) 10 on the list The Best 2000s Drama Series
Jerry Orbach, Jesse L. Martin, Dennis Farina

Premiered: 1990

Number of Seasons: 20

Number of Episodes: 456

Network: NBC

Law & Order is an American police procedural and legal drama television series, created by Dick Wolf and part of the Law & Order franchise. It originally aired on NBC and, in ...more

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11
Prison Break is listed (or ranked) 11 on the list The Best 2000s Drama Series
Dominic Purcell, Wentworth Miller, Amaury Nolasco

Premiered: 2005

Number of Seasons: 4

Number of Episodes: 81

Network: Fox Broadcasting Company

Prison Break (Fox, 2005) is an American television serial drama created by Paul Scheuring.The series revolves around two brothers; one has been sentenced for a something he did not commit, and ...more

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12
Dexter is listed (or ranked) 12 on the list The Best 2000s Drama Series
Michael C. Hall, Jennifer Carpenter, David Zayas

Premiered: 2006

Number of Seasons: 8

Number of Episodes: 96

Network: Showtime

Dexter (Showtime, 2006) is an American television drama series. Set in Miami, the series centers on Dexter Morgan, a blood spatter pattern analyst for Miami Metro Police Department who also ...more

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13
Burn Notice is listed (or ranked) 13 on the list The Best 2000s Drama Series
Jeffrey Donovan, Gabrielle Anwar, Bruce Campbell

Premiered: 2007

Number of Seasons: 6

Number of Episodes: 90

Network: USA Network

Burn Notice (USA, 2007) is an American action crime drama television series created by Matt Nix. A spy recently disavowed by the U.S. government uses his special ops training to help others in ...more

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14
Smallville is listed (or ranked) 14 on the list The Best 2000s Drama Series
Tom Welling, Michael Rosenbaum, Allison Mack

Premiered: 2001

Number of Seasons: 10

Number of Episodes: 217

Network: The WB Television Network, The CW Television Network

Smallville is an American television series developed by writer-producers Alfred Gough and Miles Millar, based on the DC Comics character Superman created by Jerry Siegel and Joe Shuster. The ...more

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15
ER is listed (or ranked) 15 on the list The Best 2000s Drama Series
Anthony Edwards, George Clooney, Julianna Margulies

Premiered: 1994

Number of Seasons: 15

Number of Episodes: 331

Network: NBC

ER is an American medical drama television series created by novelist Michael Crichton that aired on NBC from September 19, 1994, to April 2, 2009. It was produced by Constant c Productions and ...more

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16
White Collar is listed (or ranked) 16 on the list The Best 2000s Drama Series
Matt Bomer, Tim DeKay, Willie Garson

Premiered: 2009

Number of Seasons: 4

Number of Episodes: 56

Network: USA Network

White Collar is a USA Network television series created by Jeff Eastin, starring Tim DeKay as FBI Special Agent Peter Burke and Matt Bomer as Neal Caffrey, a highly intelligent and ...more

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17
CSI: Crime Scene Investi... is listed (or ranked) 17 on the list The Best 2000s Drama Series
Laurence Fishburne, Marg Helgenberger, George Eads

Premiered: 2000

Number of Seasons: 15

Number of Episodes: 337

Network: CBS

CSI: Crime Scene Investigation (CBS, 2000) is an American crime drama television series created by Anthony E. Zuiker. The series follows Las Vegas CSIs working for the Las Vegas Police ...more

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18
One Tree Hill is listed (or ranked) 18 on the list The Best 2000s Drama Series
Chad Michael Murray, James Lafferty, Hilarie Burton

Premiered: 2003

Number of Seasons: 9

Number of Episodes: 187

Network: The WB Television Network, The CW Television Network

One Tree Hill is an American television drama series created by Mark Schwahn, which premiered on September 23, 2003 on The WB. After the series' third season, The WB merged with UPN to form The ...more

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19
Sons of Anarchy is listed (or ranked) 19 on the list The Best 2000s Drama Series
Charlie Hunnam, Katey Sagal, Mark Boone Junior

Premiered: 2008

Number of Seasons: 7

Network: FX

Watch for Free with Amazon Prime Free Trial Sons of Anarchy (FX, 2008) is a television drama series created by Kurt Sutter. A biker struggles to balance being a father and being involved in an outlaw motorcycle club.

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20
Lost is listed (or ranked) 20 on the list The Best 2000s Drama Series
Naveen Andrews, Matthew Fox, Jorge Garcia

Premiered: 2004

Number of Seasons: 6

Number of Episodes: 121

Network: American Broadcasting Company

Lost is an American television drama series that originally aired on the American Broadcasting Company from September 22, 2004, to May 23, 2010, over six seasons, comprising a total of 121 ...more

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21
24 is listed (or ranked) 21 on the list The Best 2000s Drama Series
Kiefer Sutherland, Mary Lynn Rajskub, Carlos Bernard

Premiered: 2001

Number of Seasons: 9

Number of Episodes: 204

Network: Fox Broadcasting Company

Watch for Free with Amazon Prime Free Trial 24 (Fox, 2001) is an American drama television series created by Joel Surnow and Robert Cochran. Jack Bauer (Kiefer Sutherland), Director of Field Ops for the Counter-Terrorist Unit of Los ...more

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22
Grey's Anatomy is listed (or ranked) 22 on the list The Best 2000s Drama Series
Ellen Pompeo, Justin Chambers, Chandra Wilson

Premiered: 2005

Number of Seasons: 16

Number of Episodes: 356

Network: ABC

Grey's Anatomy (ABC, 2005) is an American medical soap opera television series. The series focuses on the fictional lives of surgical interns and residents as they gradually evolve into seasoned ...more

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23
Veronica Mars is listed (or ranked) 23 on the list The Best 2000s Drama Series
Kristen Bell, Percy Daggs III, Teddy Dunn

Premiered: 2004

Number of Seasons: 3

Number of Episodes: 64

Network: UPN, The CW Television Network

Watch for Free with Amazon Prime Free Trial Veronica Mars (UPN, The CW, 2004) is an American teen noir mystery drama television series created by screenwriter Rob Thomas. After her best friend (Amanda Seyfried) is murdered, and her father ...more

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24
Grimm is listed (or ranked) 24 on the list The Best 2000s Drama Series
sunfyre added David Giuntoli, Silas Weir Mitchell, Sasha Roiz

Premiered: 2011

Number of Seasons: 2

Number of Episodes: 44

Network: NBC

Grimm (NBC, 2011) is an American fantasy police procedural drama television series created by Stephen Carpenter, Jim Kouf, and David Greenwalt, inspired by stories from The Brothers Grimm. ...more

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25
Freaks and Geeks is listed (or ranked) 25 on the list The Best 2000s Drama Series
Linda Cardellini, John Francis Daley, James Franco

Premiered: 1999

Number of Seasons: 1

Number of Episodes: 18

Network: NBC

Freaks and Geeks (NBC, 1999) is an American teen comedy-drama television series created by Paul Feig. A gifted high schooler (Linda Cardellini) starts hanging out with a group of burnouts, while ...more

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