Entertainment

The Best 2000s Drama Series  

Ranker TV
1.7k votes 289 voters 7.8k views 45 items

List Rules Vote up your favorite dramas that aired on TV in the 2000s

In the mood to catch up some TV you might have missed? This is a good place to start. These are the best 2000s drama series, ranked from best to worst by user votes. From 2000s drama TV series about serial killers, to other good 2000s drama series about mob bosses, a mysterious island, and even vampires!

What shows will you find on this best 2000s drama series list? The Sopranos appears near the top of our list. The 2007 finale of this great 2000s drama show pulled in a whopping 11.9 million viewers who wanted to see how this epic mob story would end. Another good HBO drama from the 2000s was The Wire, starring Dominic West, Idris Alba and Michael K. Williams.

Medical dramas were also quite popular in the 2000s with Grey's Anatomy among the best. Other good shows on this top 2000s drama series list include The Vampire Diaries, Law & Order: Special Victims Unit and Dexter.

Which great 2000s drama should get the top spot on this list? Vote up your favorites!
list ordered by
1
House is listed (or ranked) 1 on the list The Best 2000s Drama Series
Hugh Laurie, Omar Epps, Robert Sean Leonard
House is an American television medical drama that originally ran on the Fox network for eight seasons, from November 16, 2004 to May 21, 2012. The show's main character is Dr. Gregory House, a ...more
2
Criminal Minds is listed (or ranked) 2 on the list The Best 2000s Drama Series
Shemar Moore, Matthew Gray Gubler, Thomas Gibson
Criminal Minds is an American police-procedural television program that premiered September 22, 2005, on CBS. The series follows a team of profilers from the FBI's Behavioral Analysis Unit based ...more
3
Castle is listed (or ranked) 3 on the list The Best 2000s Drama Series
Nathan Fillion, Stana Katic, Susan Sullivan
Castle is an American drama television series, which premiered on ABC on March 9, 2009. The series is produced jointly by Beacon Pictures and ABC Studios. Created by Andrew W. Marlowe, it ...more
4
Law & Order: Special Victims U... is listed (or ranked) 4 on the list The Best 2000s Drama Series
Mariska Hargitay, Christopher Meloni, Ice-T
Law & Order: Special Victims Unit is an American police procedural, legal, crime drama television series set in New York City, where it is also primarily produced. In the style of the ...more
5
Prison Break is listed (or ranked) 5 on the list The Best 2000s Drama Series
Dominic Purcell, Wentworth Miller, Amaury Nolasco
Prison Break is an American television serial drama created by Paul Scheuring, that was broadcast on Fox for four seasons, from 2005 until 2009. The series revolves around two brothers; one has ...more
6
Bones is listed (or ranked) 6 on the list The Best 2000s Drama Series
Emily Deschanel, David Boreanaz, Michaela Conlin
Bones is an American procedural comedy-drama television series that premiered on Fox in the United States on September 13, 2005. The show is based on forensic anthropology and forensic ...more
7
Law & Order is listed (or ranked) 7 on the list The Best 2000s Drama Series
Jerry Orbach, Jesse L. Martin, Dennis Farina
Law & Order is an American police procedural and legal drama television series, created by Dick Wolf and part of the Law & Order franchise. It originally aired on NBC and, in ...more
8
The Sopranos is listed (or ranked) 8 on the list The Best 2000s Drama Series
James Gandolfini, Lorraine Bracco, Edie Falco
Watch for Free with Amazon Prime Free Trial The Sopranos is an American drama television series created by David Chase. Revolving around the fictional New Jersey-based Italian-American Tony Soprano, the show portrays the difficulties he ...more
9
Burn Notice is listed (or ranked) 9 on the list The Best 2000s Drama Series
Jeffrey Donovan, Gabrielle Anwar, Bruce Campbell
Burn Notice is an American television series created by Matt Nix which originally aired on the USA Network from June 28, 2007 to September 12, 2013. The show stars Jeffrey Donovan, Gabrielle ...more
10
ER is listed (or ranked) 10 on the list The Best 2000s Drama Series
Anthony Edwards, George Clooney, Julianna Margulies
ER is an American medical drama television series created by novelist Michael Crichton that aired on NBC from September 19, 1994, to April 2, 2009. It was produced by Constant c Productions and ...more
11
White Collar is listed (or ranked) 11 on the list The Best 2000s Drama Series
Matt Bomer, Tim DeKay, Willie Garson
White Collar is a USA Network television series created by Jeff Eastin, starring Tim DeKay as FBI Special Agent Peter Burke and Matt Bomer as Neal Caffrey, a highly intelligent and ...more
12
Breaking Bad is listed (or ranked) 12 on the list The Best 2000s Drama Series
Bryan Cranston, Aaron Paul, Anna Gunn
Breaking Bad is an American drama television series created and produced by Vince Gilligan. The show originally aired on the AMC network for five seasons, from January 20, 2008, to September 29, ...more
13
Dexter is listed (or ranked) 13 on the list The Best 2000s Drama Series
Michael C. Hall, Jennifer Carpenter, David Zayas
Dexter is an American television drama series. Set in Miami, the series centers on Dexter Morgan, a blood spatter pattern analyst for Miami Metro Police Department who also leads a secret life ...more
14
Veronica Mars is listed (or ranked) 14 on the list The Best 2000s Drama Series
Kristen Bell, Percy Daggs III, Teddy Dunn
Watch for Free with Amazon Prime Free Trial Veronica Mars (UPN, The CW, 2004) is an American teen noir mystery drama television series created by screenwriter Rob Thomas. After her best friend (Amanda Seyfried) is murdered, and her father ...more
15
24 is listed (or ranked) 15 on the list The Best 2000s Drama Series
Kiefer Sutherland, Mary Lynn Rajskub, Carlos Bernard
Watch for Free with Amazon Prime Free Trial 24 is an American television series produced for the Fox network created by Joel Surnow and Robert Cochran, and starring Kiefer Sutherland as Counter Terrorist Unit agent Jack Bauer. Each ...more
16
Sons of Anarchy is listed (or ranked) 16 on the list The Best 2000s Drama Series
Charlie Hunnam, Katey Sagal, Mark Boone Junior
Watch for Free with Amazon Prime Free Trial Sons of Anarchy is an American drama television series created by Kurt Sutter, about the lives of a close-knit outlaw motorcycle club operating in Charming, a fictional town in California's ...more
17
CSI: Crime Scene Investigation is listed (or ranked) 17 on the list The Best 2000s Drama Series
Laurence Fishburne, Marg Helgenberger, George Eads
This show is an American drama television series that premiered on CBS on October 6, 2000. The show was created by Anthony E. Zuiker and produced by Jerry Bruckheimer. It is filmed primarily at ...more
18
NCIS is listed (or ranked) 18 on the list The Best 2000s Drama Series
Mark Harmon, Michael Weatherly, Pauley Perrette
NCIS is an American police procedural drama television series, revolving around a fictional team of special agents from the Naval Criminal Investigative Service, which conducts investigations ...more
19
The Vampire Diaries is listed (or ranked) 19 on the list The Best 2000s Drama Series
Nina Dobrev, Paul Wesley, Ian Somerhalder
The Vampire Diaries is an American supernatural drama television series developed by Kevin Williamson and Julie Plec, based on the popular book series of the same name written by L. J. Smith. ...more
20
Freaks and Geeks is listed (or ranked) 20 on the list The Best 2000s Drama Series
Linda Cardellini, John Francis Daley, James Franco
Freaks and Geeks is an American teen comedy-drama television series, created by Paul Feig with Judd Apatow as executive producer, that aired on NBC during the 1999–2000 television season. ...more
21
Smallville is listed (or ranked) 21 on the list The Best 2000s Drama Series
Tom Welling, Michael Rosenbaum, Allison Mack
Smallville is an American television series developed by writer-producers Alfred Gough and Miles Millar, based on the DC Comics character Superman created by Jerry Siegel and Joe Shuster. The ...more
22
One Tree Hill is listed (or ranked) 22 on the list The Best 2000s Drama Series
Chad Michael Murray, James Lafferty, Hilarie Burton
One Tree Hill is an American television drama series created by Mark Schwahn, which premiered on September 23, 2003 on The WB. After the series' third season, The WB merged with UPN to form The ...more
23
Lost is listed (or ranked) 23 on the list The Best 2000s Drama Series
Naveen Andrews, Matthew Fox, Jorge Garcia
Lost is an American television drama series that originally aired on the American Broadcasting Company from September 22, 2004, to May 23, 2010, over six seasons, comprising a total of 121 ...more
24
Grey's Anatomy is listed (or ranked) 24 on the list The Best 2000s Drama Series
Ellen Pompeo, Justin Chambers, Chandra Wilson
Grey's Anatomy is an American medical soap opera television series that premiered on American Broadcasting Company as a mid-season replacement on March 27, 2005. The series has aired eleven ...more
25
Alias is listed (or ranked) 25 on the list The Best 2000s Drama Series
sunfyre added Jennifer Garner, Ron Rifkin, Carl Lumbly
Alias is an American spy-action television series created by J. J. Abrams, which was broadcast on ABC for five seasons, from September 30, 2001, to May 22, 2006. It stars Jennifer Garner as ...more