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The Best 2000s Drama Series 

Ranker TV
Updated November 5, 2019 2.1k votes 329 voters 10.2k views 45 items

List Rules Vote up your favorite dramas that aired on TV in the 2000s

In the mood to catch up some TV you might have missed? This is a good place to start. These are the best 2000s drama series, ranked from best to worst by user votes. From 2000s drama TV series about serial killers, to other good 2000s drama series about mob bosses, a mysterious island, and even vampires!

What shows will you find on this best 2000s drama series list? The Sopranos appears near the top of our list. The 2007 finale of this great 2000s drama show pulled in a whopping 11.9 million viewers who wanted to see how this epic mob story would end. Another good HBO drama from the 2000s was The Wire, starring Dominic West, Idris Alba and Michael K. Williams.

Medical dramas were also quite popular in the 2000s with Grey's Anatomy among the best. Other good shows on this top 2000s drama series list include The Vampire Diaries, Law & Order: Special Victims Unit and Dexter.

Which great 2000s drama should get the top spot on this list? Vote up your favorites!
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1
House is listed (or ranked) 1 on the list The Best 2000s Drama Series
Hugh Laurie, Omar Epps, Robert Sean Leonard

Premiered: 2004

House, M.D. (Fox, 2004) is an American television medical drama created by David Shore. An antisocial maverick doctor (Hugh Laurie) who specializes in diagnostic medicine does whatever it takes ...more

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2
Criminal Minds is listed (or ranked) 2 on the list The Best 2000s Drama Series
Shemar Moore, Matthew Gray Gubler, Thomas Gibson

Premiered: 2005

Criminal Minds (CBS, 2005) is an American police-procedural television program. The series follows a team of profilers from the FBI's Behavioral Analysis Unit based in Quantico, Virginia. The ...more

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3
Breaking Bad is listed (or ranked) 3 on the list The Best 2000s Drama Series
Bryan Cranston, Aaron Paul, Anna Gunn

Premiered: 2008

Breaking Bad (AMC, 2008) is an American neo-Western crime drama television series created by Vince Gilligan. After being diagnosed with cancer, a depressed high school chemistry teacher (Bryan ...more

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4
Bones is listed (or ranked) 4 on the list The Best 2000s Drama Series
Emily Deschanel, David Boreanaz, Michaela Conlin

Premiered: 2005

Bones (Fox, 2005) is an American procedural comedy-drama television series created by Hart Hanson. Forensic anthropologist Dr. Temperance "Bones" Brennan (Emily Deschanel) and cocky ...more

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5
Castle is listed (or ranked) 5 on the list The Best 2000s Drama Series
Nathan Fillion, Stana Katic, Susan Sullivan

Premiered: 2009

Castle (ABC, 2009) is an American crime-comedy-drama television series created by Andrew W. Marlowe. A homicide detective (Stana Katic) reluctantly works with a best-selling mystery novelist ...more

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6
Law & Order: Special... is listed (or ranked) 6 on the list The Best 2000s Drama Series
Mariska Hargitay, Christopher Meloni, Ice-T

Premiered: 1999

Law & Order: Special Victims Unit (NBC, 1999) is an American police procedural, legal, crime drama television series set in New York City. In the style of the original Law & Order, ...more

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7
The Sopranos is listed (or ranked) 7 on the list The Best 2000s Drama Series
James Gandolfini, Lorraine Bracco, Edie Falco

Premiered: 1999

Watch for Free with Amazon Prime Free Trial The Sopranos (HBO, 1999) is an American crime drama television series created by David Chase. New Jersey mob boss Tony Soprano (James Gandolfini) deals with personal and professional issues in ...more

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8
Burn Notice is listed (or ranked) 8 on the list The Best 2000s Drama Series
Jeffrey Donovan, Gabrielle Anwar, Bruce Campbell

Premiered: 2007

Burn Notice (USA, 2007) is an American action crime drama television series created by Matt Nix. After being disavowed by the U.S. government, a covert ops agent (Jeffrey Donovan) uses his ...more

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9
NCIS is listed (or ranked) 9 on the list The Best 2000s Drama Series
Mark Harmon, Michael Weatherly, Pauley Perrette

Premiered: 2003

NCIS is an American police procedural drama television series, revolving around a fictional team of special agents from the Naval Criminal Investigative Service, which conducts investigations ...more

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10
Law & Order is listed (or ranked) 10 on the list The Best 2000s Drama Series
Jerry Orbach, Jesse L. Martin, Dennis Farina

Premiered: 1990

Law & Order is an American police procedural and legal drama television series, created by Dick Wolf and part of the Law & Order franchise. It originally aired on NBC and, in ...more

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All The Detectives From 'Law & Order,' Ranked #132 of 642 The Best TV Shows To Binge Watchlisted on Longest Running US Drama Shows

11
Prison Break is listed (or ranked) 11 on the list The Best 2000s Drama Series
Dominic Purcell, Wentworth Miller, Amaury Nolasco

Premiered: 2005

Prison Break (Fox, 2005) is an American television serial drama created by Paul Scheuring.The series revolves around two brothers; one has been sentenced for a something he did not commit, and ...more

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12
Dexter is listed (or ranked) 12 on the list The Best 2000s Drama Series
Michael C. Hall, Jennifer Carpenter, David Zayas

Premiered: 2006

Dexter (Showtime, 2006) is an American crime drama mystery series developed by James Manos Jr., based on the 2004 novel Darkly Dreaming Dexter by Jeff Lindsay. When he's not doing forensic work ...more

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13
The Vampire Diaries is listed (or ranked) 13 on the list The Best 2000s Drama Series
Nina Dobrev, Paul Wesley, Ian Somerhalder

Premiered: 2009

The Vampire Diaries (The CW, 2009) is an American supernatural teen drama television series developed by Kevin Williamson and Julie Plec, based on the book series by L. J. Smith. In the ...more

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14
Smallville is listed (or ranked) 14 on the list The Best 2000s Drama Series
Tom Welling, Michael Rosenbaum, Allison Mack

Premiered: 2001

Smallville is an American television series developed by writer-producers Alfred Gough and Miles Millar, based on the DC Comics character Superman created by Jerry Siegel and Joe Shuster. The ...more

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15
Lost is listed (or ranked) 15 on the list The Best 2000s Drama Series
Naveen Andrews, Emilie de Ravin, Matthew Fox Jorge Garcia

Premiered: 2004

Lost (ABC, 2004) is an American drama television series created by Jeffrey Lieber, J. J. Abrams, and Damon Lindelof. After a horrific plane crash, a group of strangers are forced to work ...more

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16
One Tree Hill is listed (or ranked) 16 on the list The Best 2000s Drama Series
Chad Michael Murray, James Lafferty, Hilarie Burton

Premiered: 2003

One Tree Hill (The WB, 2003) is an American drama television series created by Mark Schwahn. Half-brothers Lucas (Chad Michael Murray) and Nathan Scott (James lafferty) trade between kinship and ...more

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17
ER is listed (or ranked) 17 on the list The Best 2000s Drama Series
Anthony Edwards, George Clooney, Julianna Margulies

Premiered: 1994

ER is an American medical drama television series created by novelist Michael Crichton that aired on NBC from September 19, 1994, to April 2, 2009. It was produced by Constant c Productions and ...more

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18
CSI: Crime Scene Investi... is listed (or ranked) 18 on the list The Best 2000s Drama Series
Laurence Fishburne, Marg Helgenberger, George Eads

Premiered: 2000

CSI: Crime Scene Investigation (CBS, 2000) is an American crime drama television series created by Anthony E. Zuiker. The series follows Las Vegas CSIs working for the Las Vegas Police ...more

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19
24 is listed (or ranked) 19 on the list The Best 2000s Drama Series
Kiefer Sutherland, Mary Lynn Rajskub, Carlos Bernard

Premiered: 2001

Watch for Free with Amazon Prime Free Trial 24 (Fox, 2001) is an American drama television series created by Joel Surnow and Robert Cochran. Jack Bauer (Kiefer Sutherland), Director of Field Ops for the Counter-Terrorist Unit of Los ...more

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20
White Collar is listed (or ranked) 20 on the list The Best 2000s Drama Series
Matt Bomer, Tim DeKay, Willie Garson

Premiered: 2009

White Collar (USA, 2009) is an American crime comedy-drama series created by Jeff Eastin. After being captured by the FBI, a renowned con artist (Matt Bomer) reluctantly partners up with an ...more

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21
Grey's Anatomy is listed (or ranked) 21 on the list The Best 2000s Drama Series
Ellen Pompeo, Justin Chambers, Chandra Wilson

Premiered: 2005

Grey's Anatomy (ABC, 2005) is an American medical soap opera television series created by Shonda Rhimes. A group of young doctors faces the pressure that comes from practicing medicine in a ...more

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The Best 'Grey's Anatomy' Seasons #35 of 642 The Best TV Shows To Binge Watchlisted on Longest Running US Drama Shows

22
Sons of Anarchy is listed (or ranked) 22 on the list The Best 2000s Drama Series
Charlie Hunnam, Katey Sagal, Mark Boone Junior

Premiered: 2008

Watch for Free with Amazon Prime Free Trial Sons of Anarchy (FX, 2008) is an American crime neo-Western television series created by Kurt Sutter. As vice president of an outlaw motorcycle club involved with all sorts of illegal activity, ...more

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23
Monk is listed (or ranked) 23 on the list The Best 2000s Drama Series
Tony Shalhoub, Bitty Schram, Ted Levine

Premiered: 2002

Monk (USA, 2002) is an American comedy-drama detective mystery television series created by Andy Breckman. A brilliant detective with an extreme case of OCD (Tony Shalhoub) helps the San ...more

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24
Grimm is listed (or ranked) 24 on the list The Best 2000s Drama Series
sunfyre added David Giuntoli, Silas Weir Mitchell, Sasha Roiz

Premiered: 2011

Grimm (NBC, 2011) is an American fantasy police procedural drama television series created by Stephen Carpenter, Jim Kouf, and David Greenwalt, inspired by stories from The Brothers Grimm. ...more

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25
Freaks and Geeks is listed (or ranked) 25 on the list The Best 2000s Drama Series
Linda Cardellini, John Francis Daley, James Franco

Premiered: 1999

Freaks and Geeks (NBC, 1999) is an American teen comedy-drama television series created by Paul Feig. A gifted high schooler (Linda Cardellini) starts hanging out with a group of burnouts, while ...more

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