It turns out there are some great anime with an American backdrop, but which are really worth your time? This list ranks the best anime set in America, including older titles, as well as new American anime that you may not know about.
One great example of anime set in America is Baccano!, based on the light novel series by Ryohgo Narita. In this story, set during the Prohibition era, various unconnected people, many of whom are of disrepute, begin to cross paths thanks to the creation of an immortality elixir. The title itself is Italian and means "turmoil." Another good anime about America is 91 Days, which also takes place during Prohibition and involves mobsters in the fictional Lawless, Illinois (a stand-in it would seem for Chicago).
Don't see your favorite anime set in America already? Add it to the list, so others can vote on it too!