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The Best Villains Deadpool Has Ever Faced 

Ranker Comics
Updated March 15, 2020 28k votes 3.2k voters 330.6k views 54 items

List Rules Vote up all your favorite villains that you love to see Deadpool go at it with! No heroes!

The Merc with a Mouth, or Deadpool, was created in 1991 by writer Fabian Nicieza and comic illustrator Rob Liefeld. Though Deadpool walks the line of being a villain himself, he's also fought some of the nastiest evil guys around to help save the planet and humankind... when the price is right, anyway. This anti-hero may not always feel the urge to save the day, he still displays an impressive rogue gallery, and we're here to show it to you.
 
We've listed all of Deadpool's greatest enemies on here. Who do you think is the best villain this comic book hero's ever encountered? Do you enjoy the rivalry between Deadpool and Madcap, or do you hold Death in a special place in your heart? 
Make sure to vote up all your favorite Deadpool villains, and vote down the ones you despise. Don't see the villain you love to hate on this list? Be sure to add them!
list ordered by
1
Carnage is listed (or ranked) 1 on the list The Best Villains Deadpool Has Ever Faced
2
Evil Deadpool is listed (or ranked) 2 on the list The Best Villains Deadpool Has Ever Faced
Evil Deadpool
3
Taskmaster is listed (or ranked) 3 on the list The Best Villains Deadpool Has Ever Faced
4
Apocalypse is listed (or ranked) 4 on the list The Best Villains Deadpool Has Ever Faced
5
Death is listed (or ranked) 5 on the list The Best Villains Deadpool Has Ever Faced
6
Red Hulk is listed (or ranked) 6 on the list The Best Villains Deadpool Has Ever Faced
7
Magneto is listed (or ranked) 7 on the list The Best Villains Deadpool Has Ever Faced
8
Juggernaut is listed (or ranked) 8 on the list The Best Villains Deadpool Has Ever Faced
9
Mister Sinister is listed (or ranked) 9 on the list The Best Villains Deadpool Has Ever Faced
10
Loki is listed (or ranked) 10 on the list The Best Villains Deadpool Has Ever Faced
11
Doctor Doom is listed (or ranked) 11 on the list The Best Villains Deadpool Has Ever Faced
12
Sabretooth is listed (or ranked) 12 on the list The Best Villains Deadpool Has Ever Faced
13
BULLSEYE is listed (or ranked) 13 on the list The Best Villains Deadpool Has Ever Faced
14
Crossbones is listed (or ranked) 14 on the list The Best Villains Deadpool Has Ever Faced
15
Flash Thompson is listed (or ranked) 15 on the list The Best Villains Deadpool Has Ever Faced
16
Black Panther is listed (or ranked) 16 on the list The Best Villains Deadpool Has Ever Faced
Benjaminjeune added
17
Sentinel is listed (or ranked) 17 on the list The Best Villains Deadpool Has Ever Faced
18
Green Goblin is listed (or ranked) 18 on the list The Best Villains Deadpool Has Ever Faced
Marvel 1602
19
Ajax is listed (or ranked) 19 on the list The Best Villains Deadpool Has Ever Faced
Tyler Gammon added Ajax
20
Typhoid Mary is listed (or ranked) 20 on the list The Best Villains Deadpool Has Ever Faced
21
Daken is listed (or ranked) 21 on the list The Best Villains Deadpool Has Ever Faced
22
Madcap is listed (or ranked) 22 on the list The Best Villains Deadpool Has Ever Faced
23
Black Mamba is listed (or ranked) 23 on the list The Best Villains Deadpool Has Ever Faced
Black Mamba
24
Doctor Octopus is listed (or ranked) 24 on the list The Best Villains Deadpool Has Ever Faced
25
Vertigo is listed (or ranked) 25 on the list The Best Villains Deadpool Has Ever Faced