Villainess in this medium is actually enjoying more equality thanin real live action medium, they're not limited to "seductress" role and enjoy the same complicated character and physical ability to their male counterpart. here are the list (you're free to add character!) of female villains ever appearing in manga/ anime form; whether its a true villain, an anti hero, or a hot underling
Beatrice, also known as Sayo-Beatrice , is the Golden and Endless Witch, and the primary antagonist of the series for the first four games. She is affectionately referred to as "Beato" (ベアト?) starting in Banquet of the Golden Witch. She first appears in the "Tea Party" of Legend of the Golden Witch, where she confronts Battler over his refusal to accept that his friends and family were killed by magic, and challenges him to a game in which he must prove otherwise from Turn of the Golden Witch onward. A witch who has lived for over a thousand years, she is said to appear as a cloud of golden butterflies, and has the power to summon higher demons among the 72 pillars to serve her
She's a fictional character in the Dragon Ball manga series created by Akira Toriyama. She and her brother, Android 17, were forcibly turned into cyborgs by Dr. Gero to serve his vendetta against Son Goku. The present-timeline version of the character has very little to no interest in fulfilling Gero's orders and becomes a supporting character in the series. In the alternate-timeline, Android 18 is a ruthless killer that has a reign of terror along with Android 17 over Earth that last for twenty years until they are destroyed by Trunks
Named after the mineral beryl, is the first main antagonist in the Sailor Moon series. Beryl has immense magical power, but she uses most of it to channel the life energy harvested by her servants to the entity calledQueen Metaria. In most versions of the story, she has the ability to corrupt others into serving the powers of darkness. Her generals, for instance, were once the bodyguards and best friends of Prince Endymion, and in most versions of the story she is able to use her powers to sway Tuxedo Mask into her service.