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The Best Horror Movies About Evil Experiments 

Ranker Film
Updated November 8, 2019 1.3k votes 314 voters 22.6k views 29 items

Horror movies about evil experiments often vary in subject matter. Sometimes, the experiment is on a human subject, as seen in The Fly or The Human Centipede. Other times, scary movies can be about social experiments, like in the newly released The Belko Experiment. The plot of the film is simple- coworkers in an office are pitted against each other in a kill or be killed situation.

Sometimes the experiments themselves are not evil, but the result is. Morgan is about a scientifically created "human" that loses its mind and begins to kill the scientists that helped create her. Other good scary movies about experiments gone wrong include Re-Animator, Scanners, and From Beyond.

The purpose of this list is to rank the best evil experiment horror movies, so vote up your favorites below, and add to the list if you think the scariest human experiment movie isn't already here.

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1
The Fly is listed (or ranked) 1 on the list The Best Horror Movies About Evil Experiments
Geena Davis, Jeff Goldblum, David Cronenberg

Released: 1986

Directed by: David Cronenberg

The Fly is a 1986 American science fiction horror film directed and co-written by David Cronenberg. Produced by Brooksfilms and distributed by 20th Century Fox, the film stars Jeff Goldblum, ...more

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2
Frankenstein is listed (or ranked) 2 on the list The Best Horror Movies About Evil Experiments
Boris Karloff, John Boles, Colin Clive

Released: 1931

Directed by: James Whale

Frankenstein is a 1931 horror monster film from Universal Pictures directed by James Whale and adapted from the play by Peggy Webling, which in turn is based on the novel of the same name by ...more

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3
The Belko Experiment is listed (or ranked) 3 on the list The Best Horror Movies About Evil Experiments
John Gallagher, Jr., Tony Goldwyn

Directed by: Greg McLean

The Belko Experiment is a 2016 American horror film directed by Greg McLean and written by James Gunn. In a dark social experiment, a group of 80 Americans are locked in their high-rise ...more
4
Dark City is listed (or ranked) 4 on the list The Best Horror Movies About Evil Experiments
Jennifer Connelly, Kiefer Sutherland, Melissa George

Released: 1998

Directed by: Alex Proyas

Dark City is a 1998 neo-noir science fiction film directed by Alex Proyas. The screenplay was written by Proyas, Lem Dobbs and David S. Goyer. The film stars Rufus Sewell, Kiefer Sutherland, ...more

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5
Flatliners is listed (or ranked) 5 on the list The Best Horror Movies About Evil Experiments
Julia Roberts, Kevin Bacon, Kiefer Sutherland

Released: 1990

Directed by: Joel Schumacher

Flatliners is a 1990 American sci-fi horror thriller film directed by Joel Schumacher, starring Kiefer Sutherland, Julia Roberts, Kevin Bacon, William Baldwin and Oliver Platt. Five medical ...more
6
Splice is listed (or ranked) 6 on the list The Best Horror Movies About Evil Experiments
Adrien Brody, Sarah Polley, Delphine Chanéac

Released: 2009

Directed by: Vincenzo Natali

Splice is a 2009 Canadian-French science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in ...more

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7
Re-Animator is listed (or ranked) 7 on the list The Best Horror Movies About Evil Experiments
Barbara Crampton, Jeffrey Combs, David Gale

Released: 1985

Directed by: Stuart Gordon

Re-Animator is a 1985 American science fiction horror comedy film loosely based on the H. P. Lovecraft episodic novella "Herbert West–Reanimator." Directed by Stuart Gordon, it was the ...more

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8
Scanners is listed (or ranked) 8 on the list The Best Horror Movies About Evil Experiments
Michael Ironside, Patrick McGoohan, Jennifer O'Neill

Released: 1981

Directed by: David Cronenberg

Scanners is a 1981 Canadian science-fiction horror film written and directed by David Cronenberg and starring Jennifer O'Neill, Steven Lack, Michael Ironside, and Patrick McGoohan. In the film, ...more

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9
Firestarter is listed (or ranked) 9 on the list The Best Horror Movies About Evil Experiments
Drew Barrymore, Heather Locklear, Martin Sheen

Released: 1984

Directed by: Mark L. Lester

Firestarter is a 1984 American science fiction thriller film based on Stephen King's 1980 Firestarter. The plot concerns a young girl who develops pyrokinesis and the secret government agency ...more
10
Would You Rather is listed (or ranked) 10 on the list The Best Horror Movies About Evil Experiments
Sasha Grey, Brittany Snow, June Squibb

Released: 2012

Directed by: David Guy Levy

Would You Rather is a 2012 American horror film starring Brittany Snow and Jeffrey Combs. It is based on the party game "would you rather," and centers on Snow's character, Iris, as ...more

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11
The Lazarus Effect is listed (or ranked) 11 on the list The Best Horror Movies About Evil Experiments
The Lazarus Effect Mark Duplass, Olivia Wilde, Donald Glover

Released: 2015

Directed by: David Gelb

The Lazarus Effect is a 2015 American supernatural science fiction horror film directed by David Gelb. A group of medical researchers discover a way to bring dead patients back to life.

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12
Morgan is listed (or ranked) 12 on the list The Best Horror Movies About Evil Experiments
Morgan
13
From Beyond is listed (or ranked) 13 on the list The Best Horror Movies About Evil Experiments
Barbara Crampton, Jeffrey Combs, Ken Foree

Released: 1986

Directed by: Stuart Gordon

From Beyond is a 1986 American science fiction-body horror film directed by Stuart Gordon, loosely based on the short story of the same name by H. P. Lovecraft. It was written by Dennis Paoli, ...more

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14
The Island of Dr. Moreau... is listed (or ranked) 14 on the list The Best Horror Movies About Evil Experiments
Marlon Brando, Val Kilmer, Ron Perlman

Released: 1996

Directed by: John Frankenheimer, Richard Stanley

The Island of Dr. Moreau is a 1996 American science fiction horror film, the third major film adaptation of H. G. Wells' novel The Island of Doctor Moreau, about a scientist who attempts to ...more

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15
Depraved is listed (or ranked) 15 on the list The Best Horror Movies About Evil Experiments
David Call, Joshua Leonard

Released: 2019

Directed by: Larry Fessenden

Depraved is a 2019 American horror film written and directed by Larry Fessenden. A veteran Army medic suffering from PTSD, Henry (David Call) uses body parts to construct a man, Adam (Alex ...more
16
Altered States is listed (or ranked) 16 on the list The Best Horror Movies About Evil Experiments
Drew Barrymore, William Hurt, Bob Balaban

Released: 1980

Directed by: Ken Russell

Altered States is a 1980 American science fiction-horror film adaptation of a novel by the same name by playwright and screenwriter Paddy Chayefsky in his only novel he ever wrote and his final ...more

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17
The Human Centipede (Fir... is listed (or ranked) 17 on the list The Best Horror Movies About Evil Experiments
Ashley C. Williams, Dieter Laser, Akihiro Kitamura

Released: 2009

Directed by: Tom Six

"Outside the more outré work of Takashi Miike and David Cronenberg, you won’t have seen anything quite like Dutch avant-garde artist Tom Six’s totally bizarre off-the-wall oddity. ...more

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18
The Killing Room is listed (or ranked) 18 on the list The Best Horror Movies About Evil Experiments
Nick Cannon, Chloë Sevigny, Peter Stormare

Released: 2009

Directed by: Jonathan Liebesman

The Killing Room is a 2009 psychological thriller film directed by Jonathan Liebesman and starring Chloë Sevigny, Nick Cannon, and Timothy Hutton. It premiered at the 2009 Sundance Film ...more
19
Human Experiments is listed (or ranked) 19 on the list The Best Horror Movies About Evil Experiments
Geoffrey Lewis, Lurene Tuttle, Aldo Ray

Released: 1979

Directed by: Gregory Goodell

A women in prison film starring Linda Haynes, Geoffrey Lewis and Ellen Travolta. Director/writer/producer Gregory Goodell's only feature film to be released in cinemas, this film earned its ...more
20
Blackout Experiments is listed (or ranked) 20 on the list The Best Horror Movies About Evil Experiments
Blackout Experiments
21
The Skin I Live In is listed (or ranked) 21 on the list The Best Horror Movies About Evil Experiments
Antonio Banderas, Blanca Suárez, Elena Anaya

Released: 2011

Directed by: Pedro Almodóvar

The Skin I Live In is a 2011 Spanish psychological thriller film directed by Pedro Almodóvar and based on Thierry Jonquet's novel Mygale. A brilliant plastic surgeon (Antonio Banderas), ...more

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22
The Banshee Chapter is listed (or ranked) 22 on the list The Best Horror Movies About Evil Experiments
Ted Levine, Katia Winter, Michael McMillian

Released: 2013

Directed by: Blair Erickson

Banshee Chapter is a 2013 horror film and the directorial debut of Blair Erickson. The film had its first screening at the Fantasy Filmfest on August 22, 2013 and released on video on demand on ...more
23
Eli is listed (or ranked) 23 on the list The Best Horror Movies About Evil Experiments
Charlie Shotwell, Lili Taylor, Sadie Sink

Released: 2019

Directed by: Ciaran Foy

Eli is an 2019 American horror film directed by Ciarán Foy. A boy (Charlie Shotwell) receiving treatment for his auto-immune disorder discovers that the house he's living isn't as safe as
24
The Atticus Institute is listed (or ranked) 24 on the list The Best Horror Movies About Evil Experiments
John Rubinstein, Rya Kihlstedt
25
The Experiment is listed (or ranked) 25 on the list The Best Horror Movies About Evil Experiments
Fatih Akın, Moritz Bleibtreu, Christian Berkel

Released: 2001

Directed by: Oliver Hirschbiegel

Das Experiment is a 2001 German thriller film directed by Oliver Hirschbiegel, about a social experiment, based on Mario Giordano's novel Black Box, which resembles Philip Zimbardo's Stanford ...more