Monster girl anime is a niche genre that's started to make its way into mainstream. These shows feature girls and women who aren't exactly human—instead, they're centaurs, demons, dullahan, vampires, zombies, and all manner of mythological beasts.
More often than not, they're overtly sexy, totally adorable, or some combination of the two. Monster girls in anime commonly befriend male humans. Soon enough, the man finds himself surrounded by a harem of them.
The genre has a lot of crossover with ecchi, harem, and other related genres, and it tends to include a lot of fan service—Monster Musume and Rosario + Vampire are well-known examples of this trend. There are also shows like A Centaur's Worries and Interviews With Monster Girls, which use monster girls to explore social issues.
Whichever tone you prefer, if you like your anime with some fantasy sprinkled into it, you'll probably find something you enjoy in the monster girl genre.
Kimihito Kurusu is unique, as it's one of the few harem anime in which the male protagonist avoids becoming entangled with the women surrounding him. It makes sense, given his harem is comprised of centaurs, lamia, and dullahans, and interspecies sexual activity is strictly forbidden.
How will Kimihito survive the onslaught of busty monster ladies who all want a piece of him? You'll have to watch Monster Musume to find out.
Interviews With Monster Girls
Interviews With Monster Girls is about a biology teacher who tries to learn everything he can about demi-humans, or half-human, half-monster beings that exist in this universe. Specifically, he's interested in his three students – a dullahan, a snow woman, a vampire – and his succubus co-worker.
The show uses the girls' demi-human status to reflect real world discrimination, particularly with regards to accommodations for special needs students in schools. For example, Machi, a dullahan, must carry her head around with her everywhere she goes, which means she needs to use a backpack instead of the regulation school bag. One plot line revolves around her teacher advocating for her backpack use on the basis of her physiology.
Miss Kobayashi's Dragon Maid
When computer programmer Miss Kobayashi drunkenly befriends a dragon named Tohru, she ends up with a live-in dragon maid who's madly in love with her. Through Tohru, Miss Kobayashi meets all kinds of other dragons, including a child they end up adopting and an exiled dragon goddess.
Rosario + Vampire
Yokai Academy is home to a student body full of demons, monsters, and other non-human individuals who are learning to exist alongside their human counterparts. Humans are explicitly banned from the school, and if any are found on the premises, they're killed.
That doesn't stop the extremely human Tsukune Aono from accidentally enrolling there. Rosario + Vampire is an ecchi harem comedy largely focused on fan service, so if that's your jam, add it to your watch list.