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The Best Movies About Disease Outbreaks 

Ranker Film
Originally by
Updated March 26, 2020 57k votes 10.7k voters 1.1M views 111 items

List Rules Vote up the best films that depict epidemics of airborne illnesses or other infectious diseases that threaten humanity.

A list of the best movies with disease outbreaks. Are you a fan of movies about scary infections and crazy medical pandemics? You might be surprised to find out how many movies were made with disease outbreaks in them. Browse through this list to see the best movies with disease outbreaks. Ranked in order of the most popular movie with disease outbreaks to the least popular, it will be easy to find a great movie to watch that was voted #1. If you see a good pandemic movie that you think should get a top spot, go ahead and vote for it to get it raised higher on the list.

If you don’t see your favorite disease outbreak movie listed here, go ahead and add it to the list so that others can enjoy it as much as you have. Movies like Contagion and Virus have a unique plot that leaves the viewer on the edge of their seat and eerily resemble the coronavirus outbreak that started in 2019. But there are numerous good disease outbreak films to see, many of them just as suspenseful and fascinating as the last - and many of them pretty historically accurate as well.

If you saw a favorite disease outbreak movie a long time ago but can’t remember the name, chances are you may find it on this list of the best disease outbreak movies, or this other list of the best disease outbreak TV shows. Then you can rent it or purchase it and enjoy the movie all over again! So go ahead and look through the list of best movies with disease outbreaks to find either a long-ago oldie or a brand new favorite to enjoy! One thing is certain, the next time you get an infection, you'll probably start believing you've gotten caught up in a terrible new plague. But hey, at least you'll know how to fight it off!

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1
Contagion is listed (or ranked) 1 on the list The Best Movies About Disease Outbreaks
Gwyneth Paltrow, Kate Winslet, Matt Damon

Released: 2011

Directed by: Steven Soderbergh

Contagion is a 2011 medical thriller directed by Steven Soderbergh. The film features an ensemble cast that includes Marion Cotillard, Bryan Cranston, Matt Damon, Laurence Fishburne, Jude Law, ...more

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2
28 Days Later is listed (or ranked) 2 on the list The Best Movies About Disease Outbreaks
Cillian Murphy, Christopher Eccleston, Naomie Harris

Released: 2002

Directed by: Danny Boyle

28 Days Later is a 2002 British post-apocalyptic horror film directed by Danny Boyle. The screenplay was written by Alex Garland. The film stars Cillian Murphy, Naomie Harris, Brendan Gleeson, ...more

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3
Outbreak is listed (or ranked) 3 on the list The Best Movies About Disease Outbreaks
WayneRaczek added Morgan Freeman, Kevin Spacey, Dustin Hoffman

Released: 1995

Directed by: Wolfgang Petersen

Outbreak is a 1995 American medical disaster film directed by Wolfgang Petersen and based on Richard Preston's non-fiction book The Hot Zone. The film stars Dustin Hoffman, Rene Russo, and ...more

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4
World War Z is listed (or ranked) 4 on the list The Best Movies About Disease Outbreaks
jennifercorrea76 added Brad Pitt, Matthew Fox, David Morse

Released: 2013

Directed by: Marc Forster

This film is a 2013 American apocalyptic action horror film directed by Marc Forster. The screenplay by Matthew Michael Carnahan, Drew Goddard, and Damon Lindelof is from a screen story by ...more

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5
28 Weeks Later is listed (or ranked) 5 on the list The Best Movies About Disease Outbreaks
Rose Byrne, Idris Elba, Jeremy Renner

Released: 2007

Directed by: Juan Carlos Fresnadillo

28 Weeks Later is a 2007 British-Spanish post-apocalyptic science fiction horror film, structured as a sequel to the 2002 critical and commercial success, 28 Days Later. 28 Weeks Later was ...more

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6
I Am Legend is listed (or ranked) 6 on the list The Best Movies About Disease Outbreaks
Will Smith, Emma Thompson, Salli Richardson

Released: 2007

Directed by: Francis Lawrence

I Am Legend is a 2007 American post-apocalyptic science fiction horror film directed by Francis Lawrence and starring Will Smith. It is the third feature film adaptation of Richard Matheson's ...more

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7
The Crazies is listed (or ranked) 7 on the list The Best Movies About Disease Outbreaks
Danielle Panabaker, Timothy Olyphant, Radha Mitchell

Released: 2010

Directed by: Breck Eisner

The Crazies is a 2010 American horror film directed by Breck Eisner, with a screenplay by Scott Kosar and Ray Wright. The film is a remake of the 1973 film of the same name by George A. Romero, ...more
8
12 Monkeys is listed (or ranked) 8 on the list The Best Movies About Disease Outbreaks
Brad Pitt, Bruce Willis, Christopher Plummer

Released: 1995

Directed by: Terry Gilliam

12 Monkeys, also known as Twelve Monkeys, is a 1995 American science fiction film directed by Terry Gilliam, inspired by Chris Marker's 1962 short film La Jetée, and starring Bruce ...more

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9
Resident Evil is listed (or ranked) 9 on the list The Best Movies About Disease Outbreaks
Patrick Kelly0 added Milla Jovovich, Michelle Rodriguez, Jason Isaacs

Released: 2002

Directed by: Paul W. S. Anderson

Resident Evil is a 2002 German-British-French science fiction horror film written and directed by Paul W. S. Anderson. The film stars Milla Jovovich and Michelle Rodriguez. It is the first ...more

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10
The Andromeda Strain is listed (or ranked) 10 on the list The Best Movies About Disease Outbreaks
Paula Kelly, David Wayne, Arthur Hill

Released: 1971

Directed by: Robert Wise

The Andromeda Strain is a 1971 American science fiction film produced and directed by Robert Wise. Based on Michael Crichton's 1969 novel of the same name and adapted by Nelson Gidding, the film ...more
11
The Stand is listed (or ranked) 11 on the list The Best Movies About Disease Outbreaks
Stephen King, Rob Lowe, Molly Ringwald

Released: 1994

Directed by: Mick Garris

The Stand is a 1994 American television miniseries based on the novel of the same name by Stephen King. King also wrote the teleplay, and has a cameo role in the series. It was directed by Mick ...more

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12
Children of Men is listed (or ranked) 12 on the list The Best Movies About Disease Outbreaks
Julianne Moore, Clive Owen, Michael Caine

Released: 2006

Directed by: Alfonso Cuarón

Children of Men is a 2006 science fiction thriller film directed and co-written by Alfonso Cuarón. The screenplay, based on P. D. James's 1992 novel of the same name, was credited to five ...more

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13
REC is listed (or ranked) 13 on the list The Best Movies About Disease Outbreaks
StacyWolfe added Manuela Velasco, Javier Botet, Ana Isabel Velásquez

Released: 2007

Directed by: Paco Plaza, Jaume Balagueró

REC is a 2007 Spanish horror film, co-written and directed by Jaume Balagueró and Paco Plaza. The film was shot in Barcelona, Spain and the title is an abbreviation of the word ...more

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14
Quarantine is listed (or ranked) 14 on the list The Best Movies About Disease Outbreaks
Dania Ramirez, Jennifer Carpenter, Doug Jones

Released: 2008

Directed by: John Erick Dowdle

Quarantine is a 2008 American science fiction horror film directed by John Erick Dowdle and starring Jennifer Carpenter, Jay Hernandez, Columbus Short, Greg Germann, Steve Harris, Dania Ramirez, ...more

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15
Cabin Fever is listed (or ranked) 15 on the list The Best Movies About Disease Outbreaks
Eli Roth, Cerina Vincent, Jordan Ladd

Released: 2002

Directed by: Eli Roth

Cabin Fever is a 2002 American black comedy horror film directed by Eli Roth and starring Rider Strong, Jordan Ladd, James DeBello and Giuseppe Andrews. It was produced by Lauren Moews & ...more

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16
Carriers is listed (or ranked) 16 on the list The Best Movies About Disease Outbreaks
Emily VanCamp, Chris Pine, Piper Perabo

Released: 2009

Directed by: Àlex Pastor, David Pastor

Carriers is a 2009 American post-apocalyptic horror film written and directed by Àlex and David Pastor. It stars Lou Taylor Pucci, Chris Pine, Piper Perabo and Emily VanCamp as four ...more

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17
Rise of the Planet of th... is listed (or ranked) 17 on the list The Best Movies About Disease Outbreaks
James Franco, Freida Pinto, John Lithgow

Released: 2011

Directed by: Rupert Wyatt

Rise of the Apes is in pre-production as of May 2010. This origin story for a new franchise takes place in modern day San Francisco and will star James Franco. It is currently scheduled for a ...more

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18
Dawn of the Dead is listed (or ranked) 18 on the list The Best Movies About Disease Outbreaks
johnTthomas25 added Ving Rhames, Ty Burrell, Kevin Zegers

Released: 2004

Directed by: Zack Snyder

This film is a 2004 American horror film directed by Zack Snyder in his feature film directorial debut. A remake of George A. Romero's 1978 film of the same name, it is written by James Gunn and ...more

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19
The Happening is listed (or ranked) 19 on the list The Best Movies About Disease Outbreaks
Zooey Deschanel, Mark Wahlberg, M. Night Shyamalan

Released: 2008

Directed by: M. Night Shyamalan

The Happening is a 2008 American supernatural thriller film written, co-produced, and directed by M. Night Shyamalan that follows a man, his wife, his best friend, and his friend's daughter as ...more

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20
The Crazies is listed (or ranked) 20 on the list The Best Movies About Disease Outbreaks
StacyWolfe added Lynn Lowry, Harry Spillman, Richard Liberty

Released: 1973

Directed by: George A. Romero

The Crazies is a 1973 American science fiction horror-action film about the effects of the accidental release of a military biological weapon upon the inhabitants of a small American town. The ...more

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21
The Omega Man is listed (or ranked) 21 on the list The Best Movies About Disease Outbreaks
Charlton Heston, Anthony Zerbe, Eric Laneuville

Released: 1971

Directed by: Boris Sagal

The Omega Man is a 1971 American science fiction film directed by Boris Sagal and starring Charlton Heston. It was written by John William Corrington and Joyce Corrington, based on the 1954 ...more

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22
Pandorum is listed (or ranked) 22 on the list The Best Movies About Disease Outbreaks
DickNixon added Dennis Quaid, Norman Reedus, Ben Foster

Released: 2009

Directed by: Christian Alvart

Pandorum is a German-British 2009 post-apocalyptic science fiction film, with elements of locked room mystery, horror, and survival adventure. The film was directed by Christian Alvart and ...more

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23
Slither is listed (or ranked) 23 on the list The Best Movies About Disease Outbreaks
StacyWolfe added Elizabeth Banks, Jenna Fischer, Rob Zombie

Released: 2006

Directed by: James Gunn

Slither is a 2006 American science fiction-comedy horror film written and directed by James Gunn in his directorial debut, and starring Nathan Fillion, Elizabeth Banks, Gregg Henry, and Michael ...more

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24
Flu is listed (or ranked) 24 on the list The Best Movies About Disease Outbreaks
Soo Ae, Jang Hyuk, Cha In-pyo

Released: 2013

Directed by: Kim Sung-su

Flu is a 2013 South Korean action disaster film directed by Kim Sung-su. Chaos ensues after a lethal, airborne virus infects the population of a South Korean city less than 20 kilometers from

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25
Dreamcatcher is listed (or ranked) 25 on the list The Best Movies About Disease Outbreaks
looksharp added Morgan Freeman, Timothy Olyphant, Damian Lewis

Released: 2003

Directed by: Lawrence Kasdan

Dreamcatcher is a 2003 science fiction horror film adaptation of Stephen King's novel of the same name. It was directed by Lawrence Kasdan, and co-written by Kasdan and screenwriter William ...more

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