The Best Storylines That Feature Mysterio

List Rules
Vote up the Mysterio comic book story arcs every fan must read.

Thanks to an outstanding performance by Jake Gyllenhaal as Mysterio in the MCU's Spider-Man: Far From Home, fans are running to their local comic book stores hoping to find the best stories featuring the character. He's been kicking around the Marvel Universe since the early 1960s, but seeing as 2019 marked his first appearance in a feature film, there are plenty of people who aren't as familiar with the comics who want to learn as much about him as possible.

To help with this problem, this list has compiled the 20 greatest stories, comic books, single issues, storylines, adventures, story arcs trade paperbacks, graphic novels, and tie-ins featuring Mysterio. If you've read any of them, and see your favorite down below, make sure to vote it up to see which of the best of Mysterio's stories rises to the top of the list!


  • 1
    16 VOTES

    I Hate A Mystery

    Story Found In: Friendly Neighborhood Spider-Man #11-13 (2006)

    When Peter Parker revealed to the world that he was none other than their Friendly Neighborhood Spider-Man, the revelation had several repercussions. "I Hate A Mystery" deals with the fallout Peter had while still trying to teach in his day job. Parents weren't too keen on having a superhero teach their kids, what with the ever-present threat of danger and supervillains, which is eventually what rears its ugly head in the form of Mysterio.

    Actually, it's two Mysterios! The second man to claim the name, Danny Burkhart and the third, Francis Klum both arrive to take on Spider-Man. Eventually, the first Mysterio is brought back from the dead (with a sizeable hole in his head) to help convince the school nurse that Peter needed to keep his job at the school. It's a crazy, yet fun and exciting Spider-Man/Mysterio tale every fan should have in their longbox.

    • 2
      22 VOTES

      The Menace Of... Mysterio!

      Story Found In: The Amazing Spider-Man #13 (1964)

      You can't read books starring Mysterio and skip past his first appearance! Steve Ditko and Stan Lee's early work on The Amazing Spider-Man resulted in some of Marvel Comics' best villains, and Mysterio was certainly one of them.

      In this introductory tale, Mysterio is supported by J. Jonah Jameson as a prospective crimefighter, but Spider-Man doesn't think the new "hero" is all he's cracked up to be. Not only is this a classic Spider-Man tale, but it's also a perfect introduction of an amazing villain and a must-read for anyone looking to know all about Mysterio!

      • 3
        15 VOTES

        The Madness Of Mysterio!

        Story Found In: The Amazing Spider-Man #66-67 (1968)

        "The Madness of Mysterios!" is one of the best examples of amazing storytelling in early Spider-Man comics. The story revolves around the rivalry Mysterio has with Spider-Man, and his desire to prove he's a better fighter than his nemesis. He breaks out of prison and issues a challenge over the TV airwaves for Spidey to meet him in the location of their first battle.

        When Spider-Man shows up, he's knocked out by a blast. When he wakes up, he's shrunken down to Smurf-size and has no idea how to get out of his predicament. Of course, this being Mysterio, the whole thing was an elaborate series of tricks and props, but that's hardly a comfort to our Friendly Neighborhood Spider-Man as he must run through a miniature nightmare scene in an amusement park for the delight of his nemesis.

        • 4
          6 VOTES

          Symbiote Spider-Man

          Story Found In: Symbiote Spider-Man #1-5 (2019)

          Symbiote Spider-Man is a miniseries, which was published in 2019, but features a story set within the time of the "Black Suit Saga." This was when Spider-Man was wearing the black costume, which would eventually become the villainous Venom, but at the time, Peter didn't know that.

          In the story, which takes place many years before, Spider-Man must battle against one of his most devious villains as Mysterio comes into play to cause trouble. This amazing series, written by Peter David with illustrations by Greg Land and Iban Coello, is a fantastic new take on a period from decades past.