Some of the most powerful weapons in the One Piece world are Devil Fruits - items that grant anyone who eats them supernatural powers. But while there are undeniable advantages to having a Devil Fruit, there are some drawbacks, too - and they don't guarantee a win in fights. For this list, we'll be looking at some of the best Devil Fruit vs. non-Devil Fruit fights in One Piece.
In some cases, the Devil Fruit user is at a clear advantage, and the non-user really has to struggle to take them down. Zoro's fight with Mr. 1 is an immense challenge for him, not because Mr. 1 is stronger per se, but because he can turn his body into steel blades that Zoro has to figure out how to cut through. But sometimes it's the Devil Fruit user who is at a disadvantage - Brook's Devil Fruit doesn't exactly do him much good when he's up against a master swordsman - even if that swordsman is a zombie reanimated by his shadow.