Famous Co-Stars Who Became Besties In Real Life

How They Met: Drew Barrymore and Lucy Liu starred in the 2000 action flick Charlie's Angels.

Friendship Goals: The two powerhouse females hit it off quickly on the set and got so close in fact that Liu actually took nude photos of Barrymore in her dressing room. While appearing on The Drew Barrymore Show in 2023, Barrymore told Liu she had been searching for the photos:

Barrymore: Do you know what I was actually trying to find? I'm doing a mad scramble… I was trying to find the nude photographs you took of me on the set of Charlie's in my dressing room.

Liu: I have them. I do, of course.

Barrymore: I would love to borrow them.

In the same interview, Barrymore also shared why she thinks her friendship with Liu has been so real and long-lasting:

The thing that I love about our friendship is that we have been there in all the big and important moments, we've also been there in the small moments and the casual moments and the reason we are such good friends is because it's real and we go through real stuff with each other. It's not a Hollywood fairy tale.

How They Met: J.D. and Turk's friendship was many fans' favorite part of Scrubs. It turns out that Donald Faison and Zach Braff were just doing what felt natural. The pair became lifelong besties after playing doctors on the long-running series.

Friendship Goals: Faison and Braff are your typical best bros. They exchange silly banter on Twitter, play tennis together, and even have bizarre best friend phone cases. They are so close that Braff claimed they practically invented the concept of bromance.

“It has to be real. The only way to have a real bromance is if you’re genuinely fond of each other. [Faison's] my best friend. I’m really fond of that man, I’m not ashamed to say it. And to the supporters of our bromance, I’d like to say, thank you," Braff said.

How They Met: Jennifer Aniston and Courteney Cox were an instantly recognizable duo from the moment they stepped foot in Central Perk. The pair played best friends and roommates Rachel Green and Monica Geller on the critically acclaimed hit Friends. Their on-screen chemistry made the show legendary. 

Friendship Goals: The pair have managed to stay close throughout the decades. Cox has no problem going to bat for Aniston. When Aniston was being dragged through the mud during ex-hubby Brad Pitt's divorce from Angelina Jolie, Cox was there to slam the negative press. In turn, Aniston sometimes babysits for Cox and lets her daughter, Coco, play dress up in her multi-million dollar wardrobe. That's real love!

How They Met: The fierce women met in 1993 while doing improv at Second City. They were introduced by ImprovOlympic co-founder Charna Halpern at her Chicago event.

"She said there was another new improviser in... one of her classes whom she thought I would really like. Her name was Tina and she was like me but with brown hair," Poehler recalled in her memoir Yes Please.

Tina and Amy have been a groundbreaking, patriarchy-smashing comedy duo ever since. It was totally meant to be.

Friendship Goals: The reason Tina and Amy even are Tina and Amy is because Fey convinced Poehler to move to New York and join Saturday Night Live, where Fey was a writer. Since then, they've functioned as a team and starred alongside each other in films they co-wrote (Sisters and Baby Mama are among their credits). They've done everything from tackling politics and reprising their roles as Hillary Clinton and Sarah Palin on SNL to hosting the Golden Globes.

How They Met: Matt Damon and Ben Affleck are truly best friends for life. Their bromance is running 35 years strong. The pair first met when Damon was just 10 years old and they grew up feeding their mutual passions for acting and film. The bromance finally made its on-screen debut in 1997's Good Will Hunting.

Friendship Goals:  The pair had a pretty strong Hollywood start. After co-writing and starring in Good Will Hunting, they won an Academy Award. Since then, they've worked on numerous projects together, including the HBO series Project Greenlight, but the most rewarding has been their families. Damon and Affleck regularly take their children on bromance-filled holidays. It turns out that their kids are best friends, too. Isn't that the dream?

How They Met: Sometimes, your best friends are the ones you get to spend all day with at work. Such is the life of Dunder Mifflin employees Kelly Kapoor and Ryan Howard. Mindy Kaling and B.J. Novak, the actors behind the beloved characters, totally became besties on the set of The Office.

Friendship Goals: Kaling and Novak are known to gush about each other in the press. Kaling praised her best friend and coworker for giving her a much-needed boost of confidence. The star went on to create her own TV show, The Mindy Project. She told The Guardian, “The gift he [Novak] has always given me is the utter and total belief that I am one of the greats. And, it is an intoxicating feeling.”

Since hanging out at Dunder Mifflin, the pair eventually decided to go into business together—but they're not pushing paper. They're co-authoring a book about their experience on set.