Few things are more fun than an anime character who is totally flamboyant. These fabulous boys and men aren't afraid to embrace their feminine side - but many of them do so with the utmost drama. From confident, dramatic folks with attitude to drag queens in high heels and fishnets, flamboyant anime characters are awesome.
Not every character rocking a flamboyant aesthetic is gay, although many of them are. Characters like Victor Nikiforov of Yuri!!! on ICE clearly display their love for other men, but others, like Pegasus J. Crawford from Yu-Gi-Oh!, actually fall in love with women. Others, like Yuuga Aoyama from My Hero Academia, don't send a clear message about what their orientation might be. It just goes to show that gender presentation isn't the same thing as orientation, and that flamboyant guys can be straight, bi, gay, or anything else. Also, while some of these characters do identify to some degree with femininity, none of them are confirmed to be trans women. Rather, they're men who refuse to be limited by society's expectations of what men should be.
Ayame Sohma is the snake of the Zodiac, but his personaltiy isn't especially snakelike. Instead, he's the kind of guy who has no problem telling his school principal that he's a bottom and then relaying this anecdote to his younger brother a decade later. The only person who can calm him down is the very serious Hatori, who he absolutely worships.
Victor Nikiforov is a figure skater, so being flamboyant is part of the job. But his boistrous and confident personality follows him off the rink as well - and it's part of why Yuri loves him so much.
Shuu Tsukiyama is a Ghoul, which means that he has no choice about eating humans. But that doesn't mean he can't do it in style - he actually hosts performance art events where his patrons get to eat rare delicacies. This includes Ken Kaneki, who is first impressed by Shuu's artistry, but then terrified once he learns his true intentions.
Puri Puri Prisoner is an S-class hero who is serving time in Smelly Lid Prison for sexual assault. But the seriousness of his crimes is often overlooked because of his silly, flamboyant persona.
