The greatest sarcastic TV doctor of all time, House M.D., had plenty of famous people throughout his eight-season, 177-episode-long run. These actors typically had episode-long guest appearances on House, as opposed to brief cameos, and many times these guest stars were so impressive that their performances stole the show.
- Video: YouTube
Episode: Locked InMos Def isn’t just a rapper, he’s also a heck of an actor, who shows off his talent in this episode, playing Lee, who is suffering from locked-in syndrome. We see things from Lee’s perspective, as House realizes that he’s not brain dead like another physician said he was after his bicycle accident. He communicates with House and eventually, regains voluntary movement and speaks.
- Video: YouTube
Episode: The TyrantEarl Jones’s character in this season four episode is a cutthroat dictator in Africa who finds himself a patient in the hospital, assigned to Dr. Foreman. When Foreman asks for Chase’s help treating this horrible man, Chase hides what Dibala’s actual illness is, leading to Foreman giving him incorrect treatment that kills him.
Role: President Dibala
Episode: AcceptanceOn the season two premiere episode, LL plays a death row prison inmate who committed four murders – his girlfriend, a prison guard, and two inmates. While exercising, he begins hallucinating about the people he’s killed, screaming before collapsing. He finds himself in the hospital, assigned to a cardiologist until Dr. House asks to take the case because he’s so intrigued.
- Photo: Fox
Episode: The MistakeOn this season two episode, we see the fallout of Chase making a mistake that resulted in a patient’s death. The patient was Kayla McGinley, and Hurst plays her brother Sam, who is unhappy with how long his sister had to wait to be treated. He sues the hospital and winds up settling with Cuddy, leading to Chase and House facing discipline.
Role: Sam McGinley