The Supernatural fanbase is well aware of how meta the show can get. Sam and Dean frequently make pop culture references while facing monsters and demons, which helps to lighten the mood. What makes these references so great is how cleverly they're integrated into the dialogue. The characters never lose sight of their goal at hand, but incorporate other fandoms in their dialogue.
It's worth looking back at the funny and witty references Supernatural has made to other fandoms, from the fantasy genre to science fiction and beyond