The 25 Best Sibling Duos In Anime History

List Rules
Vote up the characters whose family brings you the most joy.

For anime fans looking for double or even six times the fun and adventure in a new series, the answer is here: sibling protagonist anime. Siblings of the standard hero and heroine are lucky to have more than a name, but these series feature entire families as main characters. A few series on the list promote pairs of siblings that are part of a larger cast of characters, as seen in Gintama or Ouran High School Host Club, so while they may not be the ultimate protagonist of their shows, they influence the story, are given ample screen time, and undergo their own development.

The stories of these brothers and sisters span multiple genres, from slice of life to science fiction. The companionship and close-knit relationships between these siblings range from beautifully loyal to questionably affectionate, but their journey together is no less entertaining. Which sibling anime is the favorite? Vote up your favorite duos and dynamics!

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  • Full Metal Alchemist: Brotherhood
    1

    Full Metal Alchemist: Brotherhood

    3,074 votes
  • Blue Exorcist
    2

    Blue Exorcist

    2,510 votes

    Rin and Yukio Okumura

  • No Game No Life
    3

    No Game No Life

    1,926 votes

    Sora and Shiro.

  • Ouran Highschool Host Club
    4

    Ouran Highschool Host Club

    2,043 votes

    Hikaru and Kaoru Hitachiin