Health The Worst Drugs for You  

Brettski
Originally by
59.3k votes 7.4k voters 286k views 50 items

List Rules Vote up any substance that affects the body, regardless of legality.

There is no question that certain drugs have specific benefits when used correctly, but where do we draw the line between drugs that are helpful and drugs that are harmful? Adderall, a stimulant, is extremely beneficial when it comes to helping someone focus when it is either difficult or unachievable, but when addiction sets in and daily function can no longer persist without the aid of that drug, has the helpful/harmful line been irrevocably crossed? Are we now in the territory of the most dangerous drugs or even the worst drugs in the world?

This list seeks to engage readers in a thoughtful discourse about what the worst drugs for you really are, and not which ones are simply the most addictive drugs (though many of the worst ones will likely also be the most addictive). The important thing to remember when considering what the most harmful drugs are is that there is no solid line between bad drugs and good drugs; many will consider alcohol an innocuous substance while others would rank it above crystal meth based on personal experiences.

Most times, when people begin using any type of drug, they do it seeking some sort of benefit such as stress relief from marijuana, increased focus from Ritalin, or pain relief from morphine. When the search for pleasure becomes a quest to relieve the pain of addiction or a fractured life brought on by a drug, that is when it crosses into the harmful category.

This list, as you may have gathered with the introduction of alcohol into the conversation, is not just about the most harmful illegal drugs, it's a catch-all of prescription drugs, pharmaceuticals, and "harmless" substances like caffeine. This poll is here to gather the opinions of real people as opposed to doctors and lawmakers who would deem the majority of this list of drugs harmful if used in any situation. All of the drugs on this list of worst drugs has a positive use and a negative abuse, and the point is to sort out one from the other and determine what the worst drugs really are (based on intended use, actual use, and potential addiction and side effects).

If you think a drug has no potential benefit for its user and will only come with negative side effects, vote it up to the top of the list of most harmful drugs. If you think something has a continuing value to the user and society, vote it down and make it known you think it is a harmless drug (or at least a beneficial drug when used correctly). If you think there is a drug that's bad for you not listed, make sure to add it so it can be part of the debate on which drug is the worst for you.
list ordered by

1
2,231 528
Desomorphine is listed (or ranked) 1 on the list The Worst Drugs for You
rvrijn1980 added Desomorphine is a derivative of morphine with powerful, fast-acting opioid effects, such as sedation and analgesia. First synthesized in 1932 and patented in 1934, desomorphine was used in ...more

2
2,155 523
Heroin is listed (or ranked) 2 on the list The Worst Drugs for You
Heroin and commonly known by its street names of H, smack, boy, horse, brown, black, tar, and others is an opioid analgesic originally synthesized by C.R. Alder Wright in 1874 by adding two ...more

3
2,090 507
Methamphetamine is listed (or ranked) 3 on the list The Worst Drugs for You
Methamphetamine is a potent central nervous system stimulant of the phenethylamine and amphetamine classes that is used as a recreational drug and, rarely, to treat attention deficit ...more

4
1,638 391
Crack cocaine is listed (or ranked) 4 on the list The Worst Drugs for You
Crack cocaine is the freebase form of cocaine that can be smoked. It may also be termed rock, work, hard, iron, cavvy, base, or just crack; the Manual of Adolescent Substance Abuse Treatment ...more

5
1,182 225
Mephedrone is listed (or ranked) 5 on the list The Worst Drugs for You
modestas-kaminskas added Bath Salts Mephedrone, also known as 4-methylmethcathinone or 4-methylephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone, MCAT, and Meow Meow. It ...more

6
1,298 366
Phencyclidine is listed (or ranked) 6 on the list The Worst Drugs for You
PCP Phencyclidine, commonly initialized as PCP and known colloquially as angel dust, KJ, illy, or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits ...more

7
1,168 442
Inhalants is listed (or ranked) 7 on the list The Worst Drugs for You

8
1,041 425
K2 (AKA Spice) is listed (or ranked) 8 on the list The Worst Drugs for You
K2 (AKA Spice)

9
253 28
Fentanyl is listed (or ranked) 9 on the list The Worst Drugs for You
MattLennon(matt.justmatt.) added A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby ...more

10
1,136 526
Speed is listed (or ranked) 10 on the list The Worst Drugs for You

11
1,017 547
Oxycodone is listed (or ranked) 11 on the list The Worst Drugs for You
Oxycodone is a semisynthetic opioid synthesized from thebaine, an opioid alkaloid found in the Persian poppy and one of the many opioid alkaloids found in the opium poppy. It is an analgesic ...more

12
891 508
Morphine is listed (or ranked) 12 on the list The Worst Drugs for You
An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are ...more

13
1,080 660
Cocaine is listed (or ranked) 13 on the list The Worst Drugs for You
Cocaine is a tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" and the alkaloid suffix "-ine", forming "cocaine". It ...more

14
1,379 744
Alcohol is listed (or ranked) 14 on the list The Worst Drugs for You
Alcohol

15
695 339
Rohypnol is listed (or ranked) 15 on the list The Worst Drugs for You

16
475 287
Ketamine is listed (or ranked) 16 on the list The Worst Drugs for You
modestas-kaminskas added A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including ...more

17
743 427
Methadone is listed (or ranked) 17 on the list The Worst Drugs for You
A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine ...more

18
659 382
Barbituates is listed (or ranked) 18 on the list The Worst Drugs for You

19
625 430
Alprazolam is listed (or ranked) 19 on the list The Worst Drugs for You
JustinKim added A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter ...more

20
731 474
Opium is listed (or ranked) 20 on the list The Worst Drugs for You
Opium is the dried latex obtained from the opium poppy. Opium latex contains approximately 12% of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other ...more

21
663 449
Anabolic Steroids is listed (or ranked) 21 on the list The Worst Drugs for You

22
514 366
Methaqualone is listed (or ranked) 22 on the list The Worst Drugs for You
Quaaludes Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative–hypnotic activity of methaqualone was first noted by ...more

23
509 374
Tranquilizers is listed (or ranked) 23 on the list The Worst Drugs for You

24
644 508
Tobacco leaf extract is listed (or ranked) 24 on the list The Worst Drugs for You

25
454 360
Methylphenidate is listed (or ranked) 25 on the list The Worst Drugs for You
Methylphenidate is a central nervous system stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder, postural orthostatic ...more