Health The Worst Drugs for You  

Brettski
Originally by
56.2k votes 7k voters 274.3k views 50 items

List Rules Vote up any substance that affects the body, regardless of legality.

There is no question that certain drugs have specific benefits when used correctly, but where do we draw the line between drugs that are helpful and drugs that are harmful? Adderall, a stimulant, is extremely beneficial when it comes to helping someone focus when it is either difficult or unachievable, but when addiction sets in and daily function can no longer persist without the aid of that drug, has the helpful/harmful line been irrevocably crossed? Are we now in the territory of the most dangerous drugs or even the worst drugs in the world?

This list seeks to engage readers in a thoughtful discourse about what the worst drugs for you really are, and not which ones are simply the most addictive drugs (though many of the worst ones will likely also be the most addictive). The important thing to remember when considering what the most harmful drugs are is that there is no solid line between bad drugs and good drugs; many will consider alcohol an innocuous substance while others would rank it above crystal meth based on personal experiences.

Most times, when people begin using any type of drug, they do it seeking some sort of benefit such as stress relief from marijuana, increased focus from Ritalin, or pain relief from morphine. When the search for pleasure becomes a quest to relieve the pain of addiction or a fractured life brought on by a drug, that is when it crosses into the harmful category.

This list, as you may have gathered with the introduction of alcohol into the conversation, is not just about the most harmful illegal drugs, it's a catch-all of prescription drugs, pharmaceuticals, and "harmless" substances like caffeine. This poll is here to gather the opinions of real people as opposed to doctors and lawmakers who would deem the majority of this list of drugs harmful if used in any situation. All of the drugs on this list of worst drugs has a positive use and a negative abuse, and the point is to sort out one from the other and determine what the worst drugs really are (based on intended use, actual use, and potential addiction and side effects).

If you think a drug has no potential benefit for its user and will only come with negative side effects, vote it up to the top of the list of most harmful drugs. If you think something has a continuing value to the user and society, vote it down and make it known you think it is a harmless drug (or at least a beneficial drug when used correctly). If you think there is a drug that's bad for you not listed, make sure to add it so it can be part of the debate on which drug is the worst for you.

1
2,107 491
Desomorphine is listed (or ranked) 1 on the list The Worst Drugs for You
rvrijn1980 added Krokodil Desomorphine is a derivative of morphine with powerful, fast-acting opioid effects, such as sedation and analgesia. First synthesized in 1932 and patented in 1934, desomorphine was used in ...more

2
2,021 493
Heroin is listed (or ranked) 2 on the list The Worst Drugs for You
Heroin Heroin and commonly known by its street names of H, smack, boy, horse, brown, black, tar, and others is an opioid analgesic originally synthesized by C.R. Alder Wright in 1874 by adding two ...more

3
1,969 482
Methamphetamine is listed (or ranked) 3 on the list The Worst Drugs for You
Methamphetamine Methamphetamine is a potent central nervous system stimulant of the phenethylamine and amphetamine classes that is used as a recreational drug and, rarely, to treat attention deficit ...more

4
1,542 363
Crack cocaine is listed (or ranked) 4 on the list The Worst Drugs for You
Crack cocaine Crack cocaine is the freebase form of cocaine that can be smoked. It may also be termed rock, work, hard, iron, cavvy, base, or just crack; the Manual of Adolescent Substance Abuse Treatment ...more

5
1,104 203
Mephedrone is listed (or ranked) 5 on the list The Worst Drugs for You
modestas-kaminskas added Bath Salts Mephedrone, also known as 4-methylmethcathinone or 4-methylephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone, MCAT, and Meow Meow. It ...more

6
1,235 346
Phencyclidine is listed (or ranked) 6 on the list The Worst Drugs for You
PCP Phencyclidine, commonly initialized as PCP and known colloquially as angel dust, KJ, illy, or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits ...more

7
1,106 416
Inhalants is listed (or ranked) 7 on the list The Worst Drugs for You

8
972 405
K2 (AKA Spice) is listed (or ranked) 8 on the list The Worst Drugs for You
K2 (AKA Spice)

9
1,077 497
Speed is listed (or ranked) 9 on the list The Worst Drugs for You

10
953 517
Oxycodone is listed (or ranked) 10 on the list The Worst Drugs for You
Oxycodone Oxycodone is a semisynthetic opioid synthesized from thebaine, an opioid alkaloid found in the Persian poppy and one of the many opioid alkaloids found in the opium poppy. It is an analgesic ...more

11
830 485
Morphine is listed (or ranked) 11 on the list The Worst Drugs for You
Morphine An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are ...more

12
1,018 625
Cocaine is listed (or ranked) 12 on the list The Worst Drugs for You
Cocaine Cocaine is a tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" and the alkaloid suffix "-ine", forming "cocaine". It ...more

13
1,292 692
Alcohol is listed (or ranked) 13 on the list The Worst Drugs for You
Alcohol

14
649 319
Rohypnol is listed (or ranked) 14 on the list The Worst Drugs for You

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152 18
Fentanyl is listed (or ranked) 15 on the list The Worst Drugs for You
MattLennon(matt.justmatt.) added Fentanyl A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby ...more

16
437 260
Ketamine is listed (or ranked) 16 on the list The Worst Drugs for You
modestas-kaminskas added Ketamine A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including ...more

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706 408
Methadone is listed (or ranked) 17 on the list The Worst Drugs for You
Methadone A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine ...more

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633 365
Barbituates is listed (or ranked) 18 on the list The Worst Drugs for You

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566 405
Alprazolam is listed (or ranked) 19 on the list The Worst Drugs for You
JustinKim added Xanax A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter ...more

20
689 451
Opium is listed (or ranked) 20 on the list The Worst Drugs for You
Opium Opium is the dried latex obtained from the opium poppy. Opium latex contains approximately 12% of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other ...more

21
632 431
Anabolic Steroids is listed (or ranked) 21 on the list The Worst Drugs for You

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488 350
Methaqualone is listed (or ranked) 22 on the list The Worst Drugs for You
Quaaludes Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative–hypnotic activity of methaqualone was first noted by ...more

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480 359
Tranquilizers is listed (or ranked) 23 on the list The Worst Drugs for You

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612 483
Tobacco leaf extract is listed (or ranked) 24 on the list The Worst Drugs for You

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435 346
Methylphenidate is listed (or ranked) 25 on the list The Worst Drugs for You
Methylphenidate Methylphenidate is a central nervous system stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder, postural orthostatic ...more

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252 220
Atypical Antipsychotics is listed (or ranked) 26 on the list The Worst Drugs for You
modestas-kaminskas added Atypical Antipsychotics

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480 427
Hydrocodone is listed (or ranked) 27 on the list The Worst Drugs for You
Hydrocodone Hydrocodone is a semi-synthetic opioid synthesized from codeine, one of the opioid alkaloids found in the opium poppy. It is a narcotic analgesic used orally as an antitussive/cough suppressant, ...more

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548 586
MDMA is listed (or ranked) 28 on the list The Worst Drugs for You
MDMA MDMA is a psychoactive drug of the substituted methylenedioxyphenethylamine and substituted amphetamine classes of drugs that is consumed primarily for its euphoric and empathogenic effects. ...more

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439 401
Ritalin is listed (or ranked) 29 on the list The Worst Drugs for You

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244 239
Zanamivir is listed (or ranked) 30 on the list The Worst Drugs for You
kaylive added Zanamivir A sialic acid analog and a neuraminidase inhibitor with antiviral property. Zanamivir selectively inhibits influenza A and B virus neuraminidase, a viral surface glycoprotein, which mediates the ...more

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493 462
Adderall is listed (or ranked) 31 on the list The Worst Drugs for You
Adderall Adderall is a psychostimulant drug of the phenethylamine class used in the treatment of attention deficit hyperactivity disorder and narcolepsy. Adderall is also used as a performance and ...more

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447 423
Vicodin is listed (or ranked) 32 on the list The Worst Drugs for You

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426 472
Codeine is listed (or ranked) 33 on the list The Worst Drugs for You
Codeine Codeine or 3-methylmorphine is an opiate used for its depressant, analgesic, antitussive, antidiarrheal, antihypertensive, anxiolytic, antidepressant, sedative and hypnotic properties. It is ...more

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411 390
Clonazepam is listed (or ranked) 34 on the list The Worst Drugs for You
Clonazepam Clonazepam is a benzodiazepine drug having anxiolytic, anticonvulsant, muscle relaxant, amnestic, sedative, and hypnotic properties. It is marketed under the trade name Rivotril by Roche in ...more

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276 250
Secobarbital is listed (or ranked) 35 on the list The Worst Drugs for You
Seconal Secobarbital sodium is a barbiturate derivative drug that was patented in 1934 in the US. It possesses anaesthetic, anticonvulsant, anxiolytic, sedative, and hypnotic properties. In the United ...more

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378 370
Ambien CR is listed (or ranked) 36 on the list The Worst Drugs for You

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200 218
Typical Antipsychotics is listed (or ranked) 37 on the list The Worst Drugs for You
modestas-kaminskas added Typical Antipsychotics

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215 259
Temazepam is listed (or ranked) 38 on the list The Worst Drugs for You
Clyde88 added Temazepam Temazepam is an intermediate-acting 3-hydroxy hypnotic of the benzodiazepine class of psychoactive drugs. It is the 3-hydroxy analogue of diazepam, and one of diazepam's primary active ...more

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162 205
Venlafaxine and SNRIs is listed (or ranked) 39 on the list The Worst Drugs for You
modestas-kaminskas added Venlafaxine and SNRIs

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305 414
Salvia divinorum is listed (or ranked) 40 on the list The Worst Drugs for You
Salvia divinorum Salvia divinorum is a psychoactive plant which can induce "visions" and other hallucinatory experiences. Its native habitat is in cloud forest in the isolated Sierra Mazateca of ...more

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168 216
Venlafaxine is listed (or ranked) 41 on the list The Worst Drugs for You
modestas-kaminskas added Venlafaxine Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. This means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the ...more

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313 372
Diazepam is listed (or ranked) 42 on the list The Worst Drugs for You
Diazepam Diazepam, first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine drug. It is commonly used to treat a wide range of conditions, including anxiety, panic attacks, insomnia, seizures, ...more

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187 253
SSRIs is listed (or ranked) 43 on the list The Worst Drugs for You
modestas-kaminskas added SSRIs

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209 259
Eszopiclone is listed (or ranked) 44 on the list The Worst Drugs for You
Eszopiclone Lunesta Eszopiclone, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic which is slightly effective for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of ...more

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316 422
Tramadol is listed (or ranked) 45 on the list The Worst Drugs for You
Tramadol Tramadol is an opioid pain medication which is used to treat moderate to moderately severe pain. When taken as an immediate-release oral formulation, the onset of pain relief usually occurs ...more

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253 404
Mescaline is listed (or ranked) 46 on the list The Worst Drugs for You
Mescaline Mescaline or 3,4,5-trimethoxyphenethylamine is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects similar to those of LSD and ...more

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76 166
Metoclopramide is listed (or ranked) 47 on the list The Worst Drugs for You
blankmates added Metoclopramide Metoclopramide is a medication used mostly for stomach and esophageal problems. It belongs to the group of medications known as dopamine-receptor antagonists. It is commonly used to treat nausea ...more

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265 458
Muscle Relaxers is listed (or ranked) 48 on the list The Worst Drugs for You
Muscle Relaxers

49
276 570
Viagra is listed (or ranked) 49 on the list The Worst Drugs for You
Viagra Viagra is the drug brand name for sildenafil, which is used for the treatment of erectile disfunction in men.

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368 1,080
Cannabis is listed (or ranked) 50 on the list The Worst Drugs for You
Diego Mazzola added Marijuana Cannabis, commonly known as marijuana and by numerous other names, is a preparation of the Cannabis plant intended for use as a psychoactive drug and as medicine. Pharmacologically, the ...more