One Piece is filled with villains that are both despicable and sympathetic, successfully blurring the lines of good and bad. But when they're bad, they're downright awful. Fans will find both Emperors of the Sea below on this list, considering the atrocities Big Mom and Kaido have committed.
The most ruthless villains in One Piece include Doflamingo, who is highly considered one of the best anime villains of all time. There are a few villains whose actions are unforgivable, like Spandam and Arlong. Take a look below and vote up the most cold-blooded One Piece villains who can never be redeemed.