Although it's not a common occurance, there are a handful cool video game characters that are sisters. Sometimes the best backup in times of strife is a little help from your family, and these sisters definitely have each others back. There are lots of amazing female characters in video games, but some of the greatest are also related to each other. Some of them could even give Mario and Luigi a run for their money. In groups or in pairs, rivals or accomplices, these sisters are some of the toughest, weirdest, greatest, and most enduring video game characters of all time. From the little sisters of Bioshock to the Great Giana Sisters, we've included every pair of sisters we could think of in video game history. Vote below on your favorite sisters in video games. Are we missing a few that you really love? Let us know in the comments, and we might just add them to the list!