Button Mash

The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister) 

Devon Ashby
Updated October 3, 2019 1.2k votes 272 voters 33.3k views 15 items
Although it's not a common occurance, there are a handful cool video game characters that are sisters. Sometimes the best backup in times of strife is a little help from your family, and these sisters definitely have each others back. There are lots of amazing female characters in video games, but some of the greatest are also related to each other. Some of them could even give Mario and Luigi a run for their money. In groups or in pairs, rivals or accomplices, these sisters are some of the toughest, weirdest, greatest, and most enduring video game characters of all time. From the little sisters of Bioshock to the Great Giana Sisters, we've included every pair of sisters we could think of in video game history. Vote below on your favorite sisters in video games. Are we missing a few that you really love? Let us know in the comments, and we might just add them to the list!
1
Mileena and Kitana
Mileena and Kitana is listed (or ranked) 1 on the list The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister)
Photo:  Mortal Kombat/Warner Bros. Interactive Entertainment
Hailing from the Outer Realm, Mileena and Kitana are both ninja warriors in the the Mortal Kombat series. Mileena fights with scythes, and Kitana fights with a steel fan. 
Great characters?
2
Sophitia and Cassandra
Sophitia and Cassandra ... is listed (or ranked) 2 on the list The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister)
Photo:  Soulcaliber/Bandai Namco Entertainment
The daughters of a Greek baker, Sophitia and Cassandra are sexy supernatural warriors in the the Soulcalibur fighting series.
Great characters?
3
Anna and Nina Williams
Anna and Nina Williams ... is listed (or ranked) 3 on the list The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister)
Photo:  Tekken/Bandai Namco Studios Namco
Anna and Nina Williams are both skilled assassins in the Tekken series. They have a volatile, competitive relationship, and are often depicted as rivals.
Great characters?
4
The Little Sisters
The Little Sisters is listed (or ranked) 4 on the list The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister)
Photo:  BioShock/2K Games
Both the creepiest and most heart rending part of the Bioshock games, the Little Sisters are dangerous mutants who must be healed and restored by the player.
Great characters?