The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister)

Over 300 Ranker voters have come together to rank this list of The Greatest Video Game Sisters (But You're Glad They Aren't Your Sister)
Although it's not a common occurance, there are a handful cool video game characters that are sisters. Sometimes the best backup in times of strife is a little help from your family, and these sisters definitely have each others back. There are lots of amazing female characters in video games, but some of the greatest are also related to each other. Some of them could even give Mario and Luigi a run for their money. In groups or in pairs, rivals or accomplices, these sisters are some of the toughest, weirdest, greatest, and most enduring video game characters of all time. From the little sisters of Bioshock to the Great Giana Sisters, we've included every pair of sisters we could think of in video game history. Vote below on your favorite sisters in video games. Are we missing a few that you really love? Let us know in the comments, and we might just add them to the list!
Photo: Metaweb / GNU Free Documentation License

  • 1
    138 VOTES

    Mileena and Kitana

    Hailing from the Outer Realm, Mileena and Kitana are both ninja warriors in the the Mortal Kombat series. Mileena fights with scythes, and Kitana fights with a steel fan. 
    138 votes
  • 2
    116 VOTES

    Anna and Nina Williams

    Anna and Nina Williams are both skilled assassins in the Tekken series. They have a volatile, competitive relationship, and are often depicted as rivals.
    116 votes
  • 3
    119 VOTES

    Sophitia and Cassandra

    The daughters of a Greek baker, Sophitia and Cassandra are sexy supernatural warriors in the the Soulcalibur fighting series.
    119 votes
  • 4
    88 VOTES

    The Little Sisters

    Both the creepiest and most heart rending part of the Bioshock games, the Little Sisters are dangerous mutants who must be healed and restored by the player.
    88 votes
  • 5
    88 VOTES

    Maya and Mia Fey

    Maya and MIa Fey appear together in Phoenix Wright: Ace Attourney episode "Turnabout Sisters," in which younger sister Maya is accused of murdering her older sister, longtime character Mia Fey.
    88 votes
  • 6
    78 VOTES

    Junko and Mukuro

    Known as the Despair Sisters, Junko and Mukuro are twins who survived a harsh childhood and are now deadly student soldiers in the Dangan Ronpa franchise.
    78 votes