It's great to have a quirk...right? Well, sort of. Some quirks have some serious drawbacks for the user, which makes you wonder if it's even worth having the quirk in the first place.
Eri's quirk, Rewind, was so hard to control when she was little that she ended her father's life by mistake. And while Izuku Midoriya's One For All is undoubtedly powerful, he's had to get used to regularly shattering his entire skeleton. Not every quirk with a huge drawback is that extreme - Ochaco Uraraka's Zero Gravity just makes her nauseated. But even seemingly small things like that can be difficult to overcome.
Vote up the biggest quirk drawbacks in My Hero Academia that you'd never want to have to deal with.