What's Up, Doc? is a 1972 screwball comedy film released by Warner Bros., directed by Peter Bogdanovich and starring Barbra Streisand, Ryan O'Neal, and Madeline Kahn in her first feature film role. It was intended to pay homage to comedy films of the 1930s, especially Bringing Up Baby, as well as old Bugs Bunny cartoons. The film was a success, and became the third-highest grossing film of 1972. The film won the Writers Guild of America 1973 "Best Comedy Written Directly for the Screen" award for writers Buck Henry, David Newman and Robert Benton. It was ranked number 61 on the list of the 100 greatest comedies published by the American Film Institute, and ranked number 68 on ... more on Wikipedia